Hematopoesis

Question 1

Where does hematopoiesis happen in the first, second, and third trimesters?

Answer 1

First: Fetal Yolk sac

Second: Liver & Spleen

Third: Red bone marrow

Question 2

Where is hematopoiesis confined to in the adult?

Answer 2

-Trabecular spaces

Question 3

What are the functions of Bone Marrow?

Answer 3

• Hematopoiesis
• Immune development
• removal of damaged and old RBC’s

Question 4

What is contained within the stroma of bone marrow?

Answer 4

• Discontinuous basement

- specialized fibroblasts called retiulcar cells (Type III collagen)

Question 5

What two lineages develop from the pluripotent stem cells of the bone marrow?

Answer 5

• Myeloid

- lymphoid

Question 6

How long does erythropoeisis take?

Answer 6

-5 days

Question 7

What are the stages of erythroblast formation?

Answer 7

1. Proerythroblast
2. Basophilic Erythroblast
3. Pollychromatophilic Eryth.
4. Orthochromatophilic
5. Reticulocyte
6. Erythrocyte

Question 8

What are the general stages of granulopoeisis?

Answer 8

1. Myeloblast
2. Promyelocyte
3. Myelocyte
4. Metamyelocyte
5. Final Cell

Question 9

What is endomitosis and what cells perform it?

Answer 9

-Megakaryocyte

Question 10

What are the stages of thrombopoiesis?

Answer 10

1. Progenitor cell
2. Megakaryoblast
3. Promegakaryocyte
4. Megakaryocyte
5. Platelets

Question 11

What is a marker of B cells in the circulation?

Answer 11

-CD 20

Question 12

Important specific granules for Eosinophils?

Answer 12

-Major basic protein

Question 13

Important specific granules of Basophils?

Answer 13

• Histamine
• Heparin
• Eosinophilic Chemotactic Factor

Question 14

Important Specific Granules for Neurtrophils?

Answer 14

-lactoferrin

Question 15

Important Azurophilic granules in neutrophils?

Answer 15

• Myleoperoxidase
• Lysozyme
• Defensins