Hematology and Oncology Flashcards
1
Q
Sickle cell disease
A
valine is substituted for glutamic acid (glutamate) at position 6 of the beta global chain
2
Q
Hereditary spherocytosis
A
defect of spectrum and ankyrin
3
Q
Ret pro-oncogene causes what thyroid cancer
A
Medullary thyroid cancer. Chromosome 10
4
Q
What red cell antigen leads to entry of P.vivax
A
Duffy
5
Q
VWD inheritance
A
Type 1 and 2 is autosomal dominant
Type 3 is austomoal recessive
6
Q
Carcinoid syndrome
A
flushing, diarrhea, bronchoconstriction (wheezing) and heart failure
7
Q
Causes of drug induced hemolysis
A
primaquine, dapsone, aspirin, quinolones
Acquired autoimmune hemolysis- methyldopa, penicillin, quinine, quinidine
