Endocrinology

Question 1

What is used for thyrotoxicosis before emergency surgery?

Answer 1

Potassium perchlorate

Question 2

which medication can worsen thyroid eye disease?

Answer 2

Radio-iodine

Question 3

What features are seen in anorexia nervosa?

Answer 3

Weight loss, elevated cortisol but normal thyroid function. May see pancytopenia. There is decreased FSH, LH and estrogens. Electrolyte imbalance includes hypomagnesemia, hypocalcemia, hypokalemia and metabolic alkalosis

Question 4

What is the normal lipid profile in DMIIin white people?

Answer 4

Elevated triglycerides due to insulin resistance or insulinopaenia, low HDL and normal LDL

Question 5

PCOS

Answer 5

LH is raised. LH:FSH ratio is 3:1
Sex-hormone binding globulin is low due to insulin resistance.
Testosterone and DHEA are elevated.
Metformin: reduce insulin resistance and improve fertility
Clomiphene: ovulation induction
Clinical features:
oligomenorrhea-hirsutism-obesity-infertility

Question 6

Biochemical features in Addison’s Disease

Answer 6

Hyponatremia, hyperkalemia, hypoglycemia and increased BUN

Question 7

Conn’s syndrome

Answer 7

Hypertension, hypokalemia and metabolic alkalosis

Question 8

What is the synacthen test used for?

Answer 8

To diagnose Addison’s disease

Question 9

What is high dose dexamethasone test used for?

Answer 9

To identify pituitary adenoma vs ectopic ACTH production in Cushing’s