hematologic agents Flashcards
what is the role of heparin sulfate on vascular endothelial cells?
binds to ATIII–>significantly incr rate of thrombin & factor Xa inactivation
where is fibrinogen converted to fibrin?
the active site of thrombin (E1 site)
does the antithrombin/heparin complex inhibit thrombin when bound or only when unbound?
does NOT inhibit thrombin bound to fibrin, only binds when thrombin is not bound to fibrin
role of antithrombin/heparin complex
prevents thrombin from being inactivated at site of clot
what type of thrombosis is a platelet poor clot?
venous thrombosis
DVT–>VTE–>PE
are antiplatelet tx used for tx of DVT?
no. heparin usually administered
which type of thrombosis is platelet rich?
arterial thrombosis
antiplatelet tx useful for tx
where do arterial thrombosis normally occur?
on top of ruptured atherosclerotic plaques
what is teh most common cause of MI and ischemic strokes?
arterial thrombosis
common causes of thrombosis
cancer, A fib, placement of mechanical heart valves, lower limb orthopedic surgery, prolonged bed rest, OCP, factor V leiden
what are used in primary prevention of MI or stroke?
antiplatelet drugs
What is DAPT?
dual antiplatelet tx—>use to prevent MI, sudden cardiac death:
combo of ASA + P2Y12 antagonist
main applications of anticoagulants
tx & prevent venous thrombosis/venous thromboembolism
- A fib
- major surgeries
- cancer
- DVT, pulmonary thromboembolism
where is heparin normally found?
found in mast cells in the body, NOT in plasma
does half life of heparin change as dose increases?
yes, half life increases as dose increases
