androgen agents Flashcards
what are the 2 main functions of androgens?
- androgenic effects
2. metabolic effects
what type of cells synthesize testosterone from cholesterol?
leydig cells
what do leydig cells express to convert androstenedione to testosterone?
17-beta HSD
what is something that needs to be monitored if giving androgens to teens with delayed puberty?
use LOW doses, otherwise risk of premature closure of epiphyseal plates
in what sort of debilitated states can androgens be administered?
- severe endometriosis
- AIDS associated wasting
- prolonged immobilization
what are the 2 types of hypogonadism?
- primary: hypergonadotropic hypogonadism
2. secondary: hypogonadotropic hypogonadism
causes of hypergonadotropic hypogonadism?
- cryptorchidism
- klinefelter syndrome
- chemotx
causes of hypogonadotropic hypogonadism?
- hypothalamus/pituitary
- morbid obesity
- low testosterone in the setting of low LH & FSH
definition: decrease in circulating gonadotrophins
hypogonadotropic hypogonadism
applications of antiandrogens
- hirsutism in females
- precocious puberty in males
- BPH
- prostate cancer
- alopecia in males
which androgen drug is associated with creating false negatives with prostate cancer screening?
Finasteride/ Dutasteride
need to double values to have accurate assessment
what sort of patients respond poorly to PDE5 inhibitors?
- diabetics
- patients after radical prostactectomy
(cavernous nerve dysfxn)
which androgen drug is associated with creating false negatives with prostate cancer screening?
Finasteride/ Dutasteride
need to double values to have accurate assessment
what sort of patients respond poorly to PDE5 inhibitors?
- diabetics
- patients after radical prostactectomy
(cavernous nerve dysfxn)
why is sudden vision loss assc’d with PDE5 inhibs?
blockage of blood flow to optic nerve
