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Pharm > estrogens/progesterones > Flashcards

estrogens/progesterones Flashcards

1
Q

which 2 cells are required for estradiol synthesis?

A
  1. theca

2. granulosa

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2
Q

steroidogenesis in the ovary is regualted by what?

A

the gonadotropins (LH & FSH)

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3
Q

which phase of menstrual cycle? high frequency, low amp LH secretion; estrogen rises; endometrial proliferation

A

follicular phase

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4
Q

which phase of menstrual cycle? estrogen induced gonadotropin surge

A

ovulation

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5
Q

which phase of menstrual cycle? rise in estrogen/progesterone; endometrial differentiation

A

luteal pahse

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6
Q

what induces the gonadotropin surge at day 14?

A

estrogen

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7
Q

which hormone is involved in decr uterine contractions?

A

progesterone

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8
Q

ethinyl estradiol, mestranol - synthetic or natural?

A

synthetic estrogen

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9
Q

what are the pharmacological uses of estrogen

A
  1. hypogonadism
  2. HRT
  3. Contraception
  4. acne
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10
Q

HRT has an ____risk of breast cancer

A

increased

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11
Q

contraceptives have a ______risk of ovarian and endometrial cancer

A

decreased

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12
Q

is estrogen administered by itself for bc?

A

NEVER

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13
Q

effect of progesterone on cervical glands?

A

increaase cervical mucous viscosity

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14
Q

breakthru bleeding is assc’d with?

A

progestin only bc

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15
Q

breakthru bleeding is ____ when assc’d with estrogen, and ______when assc’d with progestin

A

mild with estrogen, moderate with progestin

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16
Q

if a person has known h/o breast cancer, what sort of bc should you give them?

A

progestin only

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17
Q

antibiotics _____contraceptive effectiveness

A

lower

18
Q

which estrogen is a natural water-soluble estrogen sulfates; need to be given in higher dose

A

Conjugated equine estrogens (Premarin)

19
Q

side effects of 19 nor progestins?

A

acne

hirsuitism

20
Q

which estrogens or progestins are 19-nortestosterone derivatives?

A
  1. Norethindrone

2. Norgestrel

21
Q

which BC are only available in progestins only

A

implantable, IUD

22
Q

what is the failure rate for combo emergency contraceptive?

A

25%

23
Q

what is the failure rate for progestin only emergency contraceptive?

A

12%, must be taken within 72 hrs post sex

24
Q

BC has drug interactions with which drugs?

A
  1. St. John’s Wort
  2. antiretrovirals
  3. anticonvulsants
  4. antibiotics
25
Q

which drug is a partial agonist; block estrogen negative feedback & used for fertility?

A

clomiphene

26
Q

when in the menstrual cycle to dose clomiphene?

A

follicular phase

27
Q

in bone, SERMs act as _____ and suppress bone resorption

A

agonist

28
Q

in endometrium, SERMS act as ______ and induce proliferation

A

partial agonist

29
Q

in pituitary & breast, SERMS act as ______ and induce hotflashes and inhibit breast proliferation

A

antagonist

30
Q

works against ER+ breast cancer, but can cause incr risk for endometrial cancer

A

tamoxifen

31
Q

tx for carcinoma, postmenopausal bone loss, no adverse effects against endometrium

A

raloxifene

32
Q

in comparison to estrogen, tamoxifen ____hot flashes

A

increases

33
Q

in comparison to estrogen, tamoxifen ____risk of breast cancer

A

decr

34
Q

MOA: Inhibit gonadal function (mild androgenic effects)- inhibition of estrogen

A

Danazol

35
Q

MOA: Aromatase inhibitor (convert androgen to estrogen)- inhib estrogen synthesis

A

Anastrozole/ Letrozole

36
Q

what is used as an abortifacient (progesterone antag)-induce delivery after fetal death or induce labor at end of 3rd trimester

A

Mifepristone

37
Q

when should mifepristone be used?

A

less than 7 wks gestation for 1st dose

38
Q

what do you f/u mifepristone dosing with/?

A

misoprostol to induce uterine contractions admin 48 hrs later

39
Q

Longer acting emergency contraceptive that can be used up to 5 days after intercourse; partial agonist

A

ulipristal

40
Q

which hormone is responsible for endometrial proliferation?

A

estrogen

41
Q

which hormone is responsible for endometrial differentiation?

A

progesterone

42
Q

what is the key regulator during the luteal phase?

A

progesterone

Pharm (20 decks)

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