Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm > antidiabetics > Flashcards

antidiabetics Flashcards

1
Q

what are the positive regulators of insulin release

A

glu, aa, incretins, epi/b2 adrenergic stimulation, vagal stimulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what are the negative regulators of insulin release

A
  1. NE/alpha-2 adrenergc stimulation

2. amylin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

which GLUT transporter is regulated by insulin?

A

GLUT4

found in muscle, adipose tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

fasting plasma glu >126?

A

diabetes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

fasting plasma glu >96

A

gestational diabetes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

fasting plasma glu > 110-125

A

pre-diabetic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

casual plasma glu >200 + sx

A

diabetes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

oral glu tolerance test >200

A

diabetes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

oral glu tolerance test 141-199 at 2 hr interval

A

pre-diabetes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

NORMAL fasting plasma glu

A

less than 110

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

list the rapid acting insulin

A
  1. Insulin Lispro
  2. Insulin aspart
  3. Insulin glulisine
  4. inhaled insulin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

short acting insulin?

A

regular insulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

intermediate acting insulin?

A

NPH (Protamine-insulin complex)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

long acting insulin

A
  1. glargine

2. determir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

mechanical pump delivery uses what type of insulin?

A

short acting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what is the most common adverse effect of insulin administration?

A

hypoglycemia

17
Q

autonomic manifestations of hypoglycemia

A

tachycardia, sweating, tremor, nausea, hunger

18
Q

neuroglycopenic manifestations of hypoglycemia

A

irritability, confusion, HA

19
Q

how to tx hypoglycemia

A

glucose, glucagon

20
Q

MOA: decr hepatic glu output, incr peripheral glu utilization, activation of hepatic enzyme AMP-activated protein kinase (AMPK)

A

metformin

21
Q

MOA: Inhib ATP-sensitive K+ channel of B cell–> insulin release

A

Sulfonylureas

Meglitinides

22
Q

MOA: Inhib brush border glucosidase enzyme and subsequent absorption of glucose

A
  1. acarbose

2. miglitol

23
Q

MOA: incr expression of GLUT4 channel

A
  1. Pioglitazone

2. Rosiglitazone

24
Q

AE: cardiovascular, weight gain, peripheral edema, hepatotoxicity, bone fractures

A

Thiazolidinediones

25
Q

which type of oral antidiabetic agent should not be given to someone with preexisting GI issues?

A

glucosidase inhibs (acarbose + Miglitol)

26
Q

which antidiabetic agents must be injected?

A
  1. Amylinomimetic

2. incretins

27
Q

which drug can cause acute pancreatitis?

A

incretins

DPP inhibitors

28
Q

AE: Nasopharyngitis, URT infections, HA, acute pancreatitis, Hemorrhagic/necrotizing pancreatitis

A
  1. Sitagliptin
  2. Saxagliptin
  3. Linagliptin
    (DPP inhibs)

Pharm (20 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions