Heart Failure Drugs

Question 1

ACE inhibitors - end with? SE?

Answer 1

-pril

SE: persistent dry cough, renal insufficiency, hyperkalemia, postural hypoTN, teratogenic (fetotoxic)

Question 2

ACE inhibitors - MOA

Answer 2

decrease afterload and preload -> increased CO

Question 3

Angiotensin receptor blockers (ARBs) - end with? SE?

Answer 3

-sartan

SE: hyperkalemia, postural hypoTN, teratogenic (fetotoxic)

Question 4

ARB - MOA

Answer 4

block AT1 receptor on heart, peripheral vasculature, and kidney

decreases preload and afterload

Question 5

Who are ARBs for?

Answer 5

pts who can’t tolerate ACE inhibitors b/c of cough

Question 6

Beta blockers - SE

Answer 6

bradycardia, hypoTN, fatigue, dizziness

Question 7

Beta blockers - beneficial effect

Answer 7

decrease HR, inhibit renin release from kidneys

Question 8

Diuretics - MOA

Answer 8

relieve pulmonary congestion and peripheral edema

decrease pre and afterload

Question 9

4 diuretics

Answer 9

bumetanide, furosemide, metolazone, torsemide

Question 10

3 ionotropic drugs

Answer 10

digoxin - lanoxin
dobutamine - dobutrex
milrinone - primacor

Question 11

Ionotropic drugs - MOA

Answer 11

regulates cytosolic Ca concentration by inhibiting Na/K ATPase pump

increase contractility’ vagal tone enhanced

Question 12

Ionotropic drugs -SE

Answer 12

narrow therapeutic index, anorexia, nausea, vomiting, blurred vision, cardiac arrhythmias, hypokalemia