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561 > CNS 3: Major Depression and Bipolar Disorders > Flashcards

CNS 3: Major Depression and Bipolar Disorders Flashcards

1
Q

6 different types of depressive disorders

A

major depressive disorder
persistent depressive disorder
bipolar disorder
seasonal depression
postpartum depression
psychotic depression

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2
Q

Neurotransmitters associated with depression

A

Norepinephrine, dopamine, serotonin

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3
Q

Fluoxetine MOA

A

inhibits serotonin (5-HT) transporters

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4
Q

Fluoxetine SE

A

sexual side effects, somnolence, insomnia, headache, hyponatremia

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5
Q

What are 3 SSRIs

A

fluoxetine, sertraline, escitalopram

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6
Q

Sertraline MOA

A

inhibits serotonin (5-HT) transporters

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7
Q

Sertraline SE

A

sexual side effects, somnolence, insomnia, headache, hyponatremia

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8
Q

Escitalopram MOA

A

inhibits serotonin (5-HT) transporters

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9
Q

Escitalopram SE

A

sexual side effects, somnolence, insomnia, headache, hyponatremia

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10
Q

Duloxetine MOA

A

inhibits serotonin and norepinephrine (NE) transporters

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11
Q

Duloxetine SE

A

sexual SE, somnolence, insomnia, headache, hyponatremia, increased HR, narrow angle glaucoma, dry mouth

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12
Q

2 different SNRI

A

duloxetine, venlafaxine

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13
Q

Venlafaxine MOA

A

inhibits serotonin and norepinephrine (NE) transporters

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14
Q

Venlafaxine SE

A

sexual SE, somnolence, insomnia, headache, hyponatremia, increased HR, narrow angle glaucoma, dry mouth

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15
Q

Amitriptyline MOA

A

inhibits NE and serotonin uptake

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16
Q

Amitriptyline SE

A

QT prolongation w/ OD, orthostatic hypoTN, tachycardia, anticholinergic effects, vivid dreams, weight gain

17
Q

Bupropion MOA

A

inhibits norepinephrine and dopamine transporters

18
Q

Bupropion SE

A

insomnia, tremors, seizures, weight loss

19
Q

Drugs for manic episodes

A

lithium, divalproex

20
Q

Drugs for depressive episodes (5)

A

lithium, lamotrigine, aripiprazole, quetiapine, risperidone

21
Q

Lithium MOA

A

neuroprotection, neurotransmitter modulation, inhibits inositol phosphate 3 at a cellular level

22
Q

Lithium acute SE

A

nausea, diarrhea, lethargy, impaired cognitive function, hand tremor

23
Q

Lithium long term SE

A

hypothyroidism, cardiac effects, weight gain, leukocytosis, acnes, psoriasis

24
Q

Classify antidepressants (5ish)

A

-tricyclics
-monoamine oxidase inhibitors
-SSRI
-SNRI
-NDRI

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