Anti-anginal drugs

Question 1

Nitrates - MOA

Answer 1

release nitric oxide -> relax vascular smooth mus

Question 2

Nitrates - SE

Answer 2

headache, OH, flushing, tachycardia, nausea

Question 3

Nitrates - clinical utility

Answer 3

acute angina relief, angina prophylaxis, HF, acute coronary syndromes

Question 4

3 examples of nitrates

Answer 4

-nitroglycerine
-isosorbide dinitrate
-isosorbide mononitrate

Question 5

Beta blockers - MOA

Answer 5

inhibits beta-adrenergic receptors; decreases HR and contractility

Question 6

Beta blockers - SE

Answer 6

fatigue, bradycardia, hypoTN, bronchospasm

Question 7

Beta blockers - clinical utility

Answer 7

angina prophylaxis, HTN, arrhythmias, HF

Question 8

Calcium channel blockers - MOA

Answer 8

inhibit Ca -> relax vascular smooth mus and decrease HR (non-dihydropyridines)

Question 9

Calcium channel blockers - SE

Answer 9

dizziness, headache, flushing, edema, constipation

Question 10

Calcium channel blockers - clinical utility

Answer 10

angina prophylaxis, HTN, arrhythmias (non-dihydropyridines)

Question 11

3 examples of Calcium channel blockers

Answer 11

nifedipine, verapamil, diltiazem

Question 12

Ranolazine - MOA

Answer 12

modulates Na and Ca channels to reduce cardiac O2 demand

Question 13

Ranolazine - SE

Answer 13

dizziness, headache, constipation, QT interval prolongation

Question 14

Ranolazine - clinical utility

Answer 14

chronic angina management (esp when first-line tx don’t work or not tolerated)