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561 > Anti-anginal drugs > Flashcards

Anti-anginal drugs Flashcards

1
Q

Nitrates - MOA

A

release nitric oxide -> relax vascular smooth mus

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2
Q

Nitrates - SE

A

headache, OH, flushing, tachycardia, nausea

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3
Q

Nitrates - clinical utility

A

acute angina relief, angina prophylaxis, HF, acute coronary syndromes

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4
Q

3 examples of nitrates

A

-nitroglycerine
-isosorbide dinitrate
-isosorbide mononitrate

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5
Q

Beta blockers - MOA

A

inhibits beta-adrenergic receptors; decreases HR and contractility

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6
Q

Beta blockers - SE

A

fatigue, bradycardia, hypoTN, bronchospasm

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7
Q

Beta blockers - clinical utility

A

angina prophylaxis, HTN, arrhythmias, HF

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8
Q

Calcium channel blockers - MOA

A

inhibit Ca -> relax vascular smooth mus and decrease HR (non-dihydropyridines)

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9
Q

Calcium channel blockers - SE

A

dizziness, headache, flushing, edema, constipation

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10
Q

Calcium channel blockers - clinical utility

A

angina prophylaxis, HTN, arrhythmias (non-dihydropyridines)

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11
Q

3 examples of Calcium channel blockers

A

nifedipine, verapamil, diltiazem

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12
Q

Ranolazine (sodium channel blocker) - MOA

A

modulates Na and Ca channels to reduce cardiac O2 demand

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13
Q

Ranolazine (sodium channel blocker) - SE

A

dizziness, headache, constipation, QT interval prolongation

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14
Q

Ranolazine (sodium channel blocker) - clinical utility

A

chronic angina management (esp when first-line tx don’t work or not tolerated)

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15
Q

Differentiate between stable angina, unstable angina, and Prinzmetal angina

A

stable - attacks have similar characteristics and pattern

unstable - frequency and severity increase over time, may be caused by thrombi

Prinzmetal - caused by acute coronary vasopasm and may occur at rest or sleep

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16
Q

PT consideration for pts on beta-blockers, Ca channel blockers, and ACE

A

monitor BP, OH

17
Q

PT consideration, recognizing what symps during tx for nitrates and beta-blockers

A

nitrates: headaches, dizziness, flushing

beta: fatigue, SOB

18
Q

What should all pts have to tx acute angina attacks

A

nitroglycerin

561 (16 decks)

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