Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

561 > CNS 1: PD and MS > Flashcards

CNS 1: PD and MS Flashcards

1
Q

6 major neurotransmitters in CNS

A

glutamate, norepinephrine, serotonin, acetylcholine, dopamine, GABA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Acetylcholine function and clinical relevance

A

-triggers mus contraction and stimulates the excretion of certain hormones

-Alzheimer’s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Dopamine function and clinical relevance

A

-involved with movement and posture

-PD and dopamine overactivity causes psychosis (Schizophrenia)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

GABA function and clinical relevance

A

-inhibitory NT; contributes to motor control and vision; regulates anxiety

-treats epilepsy and Huntington’s disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Glutamate function and clinical relevance

A

-excitatory NT

-associated w/ AD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Norepinephrine function and clinical relevance

A

-attentiveness, emotions, sleeping, learning; sympathetic actions

-mania and depression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Serotonin function and clinical relevance

A

-regulates body temp, sleep, mood, appetite, and pain

-imbalance = depression, suicide, impulsive behavior, aggressiveness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Primary pathological mechanisms and NT associated with PD

A

loss of nigrostriatal dopamine

loss of dopaminergic neurons presence of Lewy bodies in substantia nigra, reduces activation of motor cortex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Clinical symps of PD

A

TRAP

SOAP
-sleep disturbances, other misc symps (nausea, fatigue, speech, pain, dysesthesias, vision, seborrhea), autonomic symps, psychological symps

MAD
-motor fluctuations, akathisia, dyskinesia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

5 generic names for PD drugs

A

-dopamine agonists
-dopamine precursor and related agents
-monoamine oxidase (MAO) inhibitors
-catechol-o-methyl-transferase (COMT) inhibitors
-amantadine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

5 specific drugs for PD

A

levodopa, carbidopa, ropinirole, tolcapone, selegiline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Levodopa MOA

A

dopamine precursor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Levodopa SE

A

GI upset, arrhythmias, dyskinesias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Carbidopa MOA

A

Dopa decarboxylase (DDC) inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Carbidopa SE

A

GI upset, arrhythmias, dyskinesias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Ropinirole MOA

A

Dopamine D2 agonist

17
Q

Ropinirole SE

A

hallucinations, OH, dyskinesias

18
Q

Tolcapone MOA

A

Catechol-o-methyl transferase (COMT) inhibition

19
Q

Tolcapone SE

A

dyskinesias, acute liver failure

20
Q

Selegiline MOA

A

monoamine oxidase-B (MAO-B)

21
Q

Selegiline SE

A

serotonin syndrome

22
Q

4 clinical forms of MS

A

Relapsing-remitting, secondary progressive, primary progressive, progressive relapsing

23
Q

Describe relapsing-remitting

A

-early 20-30s; women 2:1
-better prognosis
-most will develop secondary progressive MS

24
Q

Describe secondary progressive

A

could represent different, advanced stage of relapsing-remitting MS

25
Q

Describe primary progressive

A

-late 30-40s; men as likely as women
-worse prognosis: supporting equipment avg 6-7 years

26
Q

Describe progressive relapsing

A

steadily worsening w/ clear acute relapses w/ or w/o recovery

27
Q

3 key pathological hallmarks of MS

A

-demyelination causes axonal damage
-loss of myelin slows and disrupts signal transmission
-repeated damage leads to axonal destruction and permanent loss of function

28
Q

8 disease modifying drugs used for the tx of MS

A

-avonex
-betaseron
-copaxone
-gilenya
-tecfidera
-novantrone
-ocrevus
-tysabri

29
Q

9 drugs used for symptomatic mgt of MS associated symptoms

A

-amantadine
-methylphenidate
-baclofen
-dantrolene
-tizanidine
-oxybutynin
-prazosin
-gabapentin
-pregabalin

30
Q

drugs used for tx of acute MS relapses (not sure if the answers are right)

A

-IV injection of corticosteroids; methylprednisolone
-oral prednisone
-adrenocorticotropic hormone (ACTH)?

31
Q

Goal for rehab when a pt is on drug holiday

A

-maintain pt mobility, ROM, CV fitness

32
Q

What type of sessions may be needed for MS pts

A

shorter and more frequent; accommodate pt’s fatigue levels

33
Q

4 common SE of MS drugs

A

muscle weakness, fatigue, dizziness, heat sensitivity

561 (16 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions