Healing and Repair Flashcards
what is a normal immune reaction targeting innocuous antigens
hypersensitivities
define hypersensitivity diseases
environment and food antigens can cause immediate and sometimes persistent release of inflammatory mediators
what is the main immunologic component of a Type 1 hypersensitivity
IgE
what are examples of a Type 1 hypersensitivity
anaphylaxis, Atopy
which hypersensitivity disease occurs when antibodies can be formed against antigens on the body’s own cells or tissues resulting in complement and cellular responses
Type 2
what is the main immunologic component of a Type 2 hypersensitivity
cytotoxic Antibodies
what are some examples of a Type 2 hypersensitivity
IMHA
Myasthenia gravis
Pemphigus foliaceus
which hypersensitivity disease occurs when there is excessive formation of antigen-antibody complexes can deposit in capillaries and activate complement and other factors
Type 3
what is the main immunologic component of Type 3 hypersensitivity
Antigen-Antibody Complex
what are some examples of a Type 3 hypersensitivity
glomerulonephritis
vasculitis
why are Type 3 hypersensitivity diseases dangerous
travel in blood
can cause necrosis by getting lodged/ jamming vessels
which hypersensitivity disease has cytotoxic T-lymphocytes hypersensitized to a host’s own cells resulting in cellular destruction
Type 4
what is the immunologic component of a Type 4 hypersensitivity
cell-mediated T-lymphocytes
what are some examples of a Type 4 hypersensitivity
Type 1 diabetes mellitus
rheumatoid arthritis
which hypersensitivity has allergen-specific IgE binding to mast cells
Type 1
which hypersensitivity has antigen-antibody complexes deposited in tissues
Type 3
which hypersensitivity has antibodies binding to cellular antigens
Type 2
which hypersensitivity has Th1 cells secrete cytokines that activate cytotoxic T-cells
Type 4
true or false
inflammation always precludes healing
false
inflammation doesn’t preclude healing
what are the overlapping components of acute inflammation and healing
neutrophils
fibrin deposition
cytokines and other factors
oxygen and nutrient delivery
what are the overlapping components of chronic inflammation and healing
macrophages
granulation tissue
cell repopulation
what are the 2 mechanisms in which tissue can heal
healing by regeneration
healing by repair
which healing process has dead cells that are replaced by an identical cell type and tissue homeostasis is restored or near-restored
healing by regeneration
which healing process has dead cells that must by replaced by another cell type (usually fibrous connective tissue)
healing by repair
what controls the type of healing that occurs
extent of injury
cell type involved
which healing process requires that the progenitor cells and underlying supportive tissue is still in place
healing by regeneration