Haemolytic Uraemic Syndrome Flashcards
1
Q
What is haemolytic uraemic syndrome?
A
Thrombosis in the small vessels throughout the body usually triggered by Shiga toxins from E coli 0157 or Shigella
2
Q
What is the classic triad of HUS?
A
- AKI
- Thrombocytopenia
- Normocytic Microangiopathic haemolytic anaemia
3
Q
What is Microangiopathic haemolytic anaemia?
A
- Small thrombi partially obstruct the small blood vessels and cause RBC to rupture
4
Q
How does HUS present?
A
- E coli and Shigella cause gastroenteritis
- First symptom is bloody diarrhoea
- Fever
- Abdo pain
- Reduced urine output
- Bruising
- Pallor
- HTN
5
Q
How is HUS investigated?
A
Stool culture to find organism
6
Q
How is HUS managed?
A
- Hospital admission
- Supportive management with fluids, manage HTN, anaemia and renal failure
- Usually self-limiting
