Goodpastures Syndrome Flashcards
1
Q
What is Goodpastures?
A
A small-vessel vasculitis caused by anti-GBM antibodies against type IV collagen
2
Q
How does Goodpastures present?
A
- Pulmonary haemorrhage
- Rapidly progressing glomerulonephritis: rapid onset AKI with proteinuria and haematuria
3
Q
How is Goodpastures investigated?
A
Renal biopsy: linear IgG deposits along the basement membrane
- Raised transfer factor secondary to pulmonary haemorrhage
4
Q
How is Goodpastures managed?
A
- Plasma exchange
- Steroids
- Cyclophosphamide