Acute Interstitial Nephritis Flashcards
1
Q
What is acute interstitial nephritis?
A
Inflammation of the renal tubulo-interstitium
2
Q
What causes AIN?
A
- Drugs mainly penicillin, rifampicin, NSAIDs, allopurinol and furosemide
- SLE/Sarocidosis/Sjogrens
- Some infections e.g. Staphy
Autoimmune:SLE/sjrogens/sarcoidosis
Infection: staph infection
NSAIDs, rifampicin, penicillin
3
Q
What is the pathophysiology of AIN?
A
Histology shows marked interstitial oedema and interstitial infiltrate in the connective tissue between renal tubules
4
Q
How does AIN present?
A
- fever, rash, arthralgia
- eosinophilia
- mild renal impairment
- hypertension
5
Q
How is AIN investigated?
A
Urinalysis shows sterile pyuria and white cell casts
6
Q
How do you differentiate between ATN and AIN?
A
AIN is an inflammatory process so there is a higher white cell content in the urine, while ATN is not so the urine has no cellular component
