gynae - pharma Flashcards
when is syntocin used
active mx of 3rdlabour // to induce labour
when is ergometrine used
active mx 3rd stage (+ reduce blood loss)
mechanism ergometrine
stimulates alpha, dopamine, serotonin –> contrict smooth muscle of utuers
SE + contraindication ergometrine
coronary artery spasm - do not give in HTN
when is mifepristone used
terminate pregenancy (progesterone antagonist)
SE mifepristone
bleeding
which antibiotics are not safe in pregnancy
tetracyclines (doxycycline) // aminoglycosides (gentamicin, neomycin) // sulphonamides + trimethroprim (co-trimox) // quinololnes (-floxacin) // chloramphenicol
other meds not good in pregnancy
ACEi, ARBs // statin // warfarin // SUR // retinoid // cytotoxic // valproate, carbamazepine, phenytoin // methotrexate, sulfonyurea
anti-oestrigen drugs
tamoxifen and aromatise inhib
action tamoxifen
selective oestrogen receptor modulator
SE tamoxifen
menstrual disrupt // hot flushes // VTE // endometrial cancer
examples aromatase inhib
anastrozole, letrozole
mechanism aromatase inhibitors
reduce peripheral oestrogen synthesis (main place of production in post menopasue)
main indication aromatase inhibitors
er+ breast cancer in post menopausal women
SE aromatase inhibitors
osteoporosis, hot fluses, arthalgia, insomnia
