gynae - pharma Flashcards
when is syntocin used
active mx of 3rdlabour // to induce labour
when is ergometrine used
active mx 3rd stage (+ reduce blood loss)
mechanism ergometrine
stimulates alpha, dopamine, serotonin –> contrict smooth muscle of utuers
SE + contraindication ergometrine
coronary artery spasm - do not give in HTN
when is mifepristone used
terminate pregenancy (progesterone antagonist)
SE mifepristone
bleeding
which antibiotics are not safe in pregnancy
tetracyclines (doxycycline) // aminoglycosides (gentamicin, neomycin) // sulphonamides + trimethroprim (co-trimox) // quinololnes (-floxacin) // chloramphenicol
other meds not good in pregnancy
ACEi, ARBs // statin // warfarin // SUR // retinoid // cytotoxic // valproate, carbamazepine, phenytoin // methotrexate, sulfonyurea
anti-oestrigen drugs
tamoxifen and aromatise inhib
action tamoxifen
selective oestrogen receptor modulator
SE tamoxifen
menstrual disrupt // hot flushes // VTE // endometrial cancer
examples aromatase inhib
anastrozole, letrozole
mechanism aromatase inhibitors
reduce peripheral oestrogen synthesis (main place of production in post menopasue)
main indication aromatase inhibitors
er+ breast cancer in post menopausal women
SE aromatase inhibitors
osteoporosis, hot fluses, arthalgia, insomnia
invx when starting aromatase inhibitors
DEXA scan
mechanism trastuzamab
monoclonal antibody against HER2
indication trastuzamab
met breast cancer
SE trastuzamab
flu + diarrhoea // cardiotoxic (esp with anrthracyclines)
congenital defect with alcohol
craniofacial
congenital defect with carbamazepine
neural tube defects
congenital defect with chloramphenicol
grey baby
congenital defect with lithium
ebsteins anomaly (right ventricle)
congenital defect with maternal DM
macrosomnia, neural tube, polhydramnios, preterm
congenital defect with smoking + cocaine
preterm, IUFR
congenital defect with tetracycline (doxy)
teeth colour
congenital defect with valproate
neural tube + craniofacial
where do ovarias drain too
para-aortic
