Gout

Question 0

First line of Tx for gout

Answer 0

NSAIDS

Question 1

Indomethacin/Indocin

Answer 1

NSAID for gout and other inflammatory conditions.
Normal NSAID sides
can also exacerbate HTN or CHF
Do not use with history of nasal or sinus polyps

Question 2

Cortisone injection

Answer 2

Steroid for short term pain relief and decreased swelling
Given by intraarticular injection (also PI, IM, IV, spray, or top)
Sides are typical steroid sides like hyperglycemia and dm,
osteoporosis, depression, etc

Question 3

Colchicine

Answer 3

mitotic inhibitor for acute gout and gout prophylaxis
binds to tubulin and inhibits mitosis. also inhibits neutrophil motility
sides:
PERIPHERAL NEUROPATHY
Gi stuff, neutropenia and hair loss
overdose> vomiting, renal failure, hypovolemic shock

Question 4

Allopurinol/Zyloprim

Answer 4

purine analog for hyperuricemia and gout
inhibits xanthine oxidase
Can cause n&v, SJS, and rash
Hypersensitivity causes the rash with a fever, hepatitis, and decreased renal fxn

Question 5

Probenecid/Probalan

Answer 5

Uricouric for hyperuricemia and gout
decreases reabsorption of uric acid so it is excreted in the urine
can cause uric acid renal stones
pt with G6P deficiency> anemia, leukopenia
gout may reappear after stopping medication
do not use with salicylates