Anti-psychotics

Question 0

Side effects of neuroleptic drugs

Answer 0

they block d2 receptors outside of the mesolimbic pathway as well:
tremors
tardive dyskinesia
blurred vision, dry mouth, constipation, urinary retention, increased prolactin release

Question 1

Neuroleptic drugs usually work where?

Answer 1

On the D2 receptors

excess dopamine in the mesolimbic pathway can lead to psycho experiences

Question 2

Neuroleptic malignant syndrome NMS

Answer 2

catatonia
fluctuating BP
dysarthria
fever
can be fatal

Question 3

Treatment of NM

Answer 3

use a dopamine agonist like bromocriptine

Question 4

Chlorpromazin/thorazine

Answer 4

typical neuroleptic for psychosis, mania, schizophrenia, n&v, intractable hiccoughs
MOA: D2 and H1 blockade
sides: parkinsonian, extrapyrimidal, increased release of prolactin

Question 5

Prochlorperazine/ compazine

Answer 5

typical neuroleptic for psychosis. also used with vertigo and nauseating migraines
primarily works at H1 histamine receptor sites but also antagonizes alpha adrenergic and D2
less extrapyrimidal sxs than others
better anti-emetic than others

Question 6

Haloperidol/Haldol

Answer 6

typical neuroleptic for psychosis, tourettes, huntingtons, and acute agitation
works at D2
must administer carefully dt excessive sedation and tardive dyskin
SIGNIFICANT NMS POSSIBILITY

Question 7

CLOZAPINE/ CLOZARIL

Answer 7

atypical neuroleptic for schizophrenia
multiple site blockade. especially works at D2 and 5-HT2
rapid absorption and extensive metabolism
sides: agranulocytosis and myocarditis

Question 8

Respiradone/risperdal

Answer 8

atypical neuroleptic for psychosis
presumed serotonin and dopamine blockade
metabolites after p450 still active
sides: the typical plus wt gain, hyperglycemia, and DM
increased risk of stroke in the elderly

Question 9

Olanzapine/ zyprexa

Answer 9

atypical neuroleptic for schizophrenia
greatest action at D2 and 5HT2 sites
rapid absorption and extensive metabolism
side: very little extrapyrimidal 
wt gain, hyperglycemia, and DM
increased stroke risk in elderly

Question 10

Lithium carbonate/ Eskalith

Answer 10

presumed to dampen transmission by Norepi and diminish response to glutamate
cleared by kidneys
very small TI
Side: wt gain, cognitive impairment, short-term memory deficit
Renal effect_> impaired concentration!!
Diabetes insipidus!!
Hypothyroid