Dementia

Question 0

Donepezil/Aricept

Answer 0

Centrally acting reversible AChE inhibitor for alzheimer’s, Lewy body, and vascular dementia

sides are parasympathetic and vivid dreams
may improve language in autism

Question 1

AChE (acetylcholine esterase) inhibition

Answer 1

Increased ACh in synaptic cleft leads to more cholinergic transmission and reduced alzheimers ssx

sides are parasympathetic- bradycardia, hypotension, increased urination and lacrimation, bronchoconstriction

Question 2

Rivastigmine/Exelon

Answer 2

Centrally acting reversible AChE inhibitor for mild parkinsons or alzheimers

PO or in patch form

Question 3

Galantanine/Razadyne

Answer 3

brain enhancer for memory used in early onset alzheimers

Question 4

Acetylcholinesterase overdose

Answer 4

n/v
salivation
sweat
bradycardia

ATROPINE IS THE ANTIDOTE

Question 5

Memantine/ Namenda

Answer 5

blocks NMDA glutamate receptors
inhibits Ca influx (both lead to less neuronal excitotoxicity)
non-competitive @ 5HT3 receptor antagonist
agonist @ D2
antagonist @ nicotinic