antidepressants

Question 0

Tricyclic antidepressants

Answer 0

Diminish reuptake of monamine neurotranmitters
Used for OCD, enuresis, panic attacks, pain, and migraines
Anticholinergic side effects
Easier to OD than other anti-depresants. Can be fatal with 10x daily dose.
Prolongs QT interval

Question 1

Generals for MAOI

Answer 1

Block the enzyme that breaks down tyramine, so foods with tyramine should be avoided. Excess tyramine leads to toxic levels of catecholamines and HTN emergencies
Large side effect profile.

Question 2

Amitriptyline/Elavil

Answer 2

Tricyclic antidepressant for major depression, bipolar, and migraine
Increases Serotonin and NE
Causes dizziness and marked drowsiness
Withdrawal possible

Question 3

Fluoxetine/Prozac

Answer 3

SSRI for major depression, OCD, bulimia, and panic disorder
potential for serotonin syndrome
Sexual dysfunction side effects

Question 4

Duloxetine/Cymbalta

Answer 4

SNRI for depression, anxiety, painful neuropathy, and fibromyalgia

Question 5

Bupropion/Wellbutrin

Answer 5

Norepinephrine and Dopamine reuptake inhibitor and a nicotine receptor antagonist
used for major depression, bipolar, ADD, and smoking cessation
Sides: HA, insomnia, dry mouth, tremors, anxiety, sweating

Question 6

Zyban

Answer 6

Wellbutrin as a smoking cessation drug.
Takes 5-7 days to reach a steady state in the blood so should be started a week before intended quit date
150 mg/day x 3 days, then 150 mg BID for 7-12 weeks

Question 7

Levomefolic acid/ Deplin

Answer 7

Folate supplement that is only available as a prescription. Enhances effectiveness of SSRI