Derm

Question 0

Increased skin penetration factors

Answer 0

decreased size
increased lipid
increased concentration
where the skin is thin
on a child

Question 1

For a topical drug to have any effect it must penetrate the

Answer 1

stratum corneum

Question 2

Polymyxin B

Answer 2

disrupts cell membrane

can be ototoxic if used with perforated TM

Question 3

Mupirocin/ Bactroban

Answer 3

great for impetigo
great for topical staph and strep (use with oral Ab for MRSA)
w/ MRSA, apply to nares as well as infx site

Question 4

Ketoconazole/ Nizarol

Answer 4

topical antifungal for tinea, yeast infx, seborrheic derm

inhibits sterol synthesis

Question 5

Potency rankings for corticosteroids

Answer 5

class 1 is the most potent, class 7 is the least
Halogenated are more potent

Question 6

Hydrocortisone/ Cortef

Answer 6

Glucocorticoid that’s anti-inflammatory
affects gene transcription
OTC t use on face or thin skin

Question 7

Tretinoin/ Retin A

Answer 7

Vitamin A derivative for acne and photo damaged skin
Reduces hyperkeratinization and thickens epidermis
Takes months of use for results
Sides: erythema, peeling, photosensitivity

Question 8

Isoretinoin/Accutane

Answer 8

vitamin A derivative for acne, rosacea, or hidradenitis supperativa
Decreases hyperkeratinization, sebum production and the bac that causes acne
Teratogenicity!!! Depression, psychosis, myalgias, hyperlipidemia

Question 9

Psoriasis tx

Answer 9

topical corticosteroids
topical vit D
phototherapy
systemics