Analgesics

Question 0

Morphine

Answer 0

opioid analgesic with a high affinity for mu receptors. also alters brain’s perception of pain
highly addictive
tolerance develops
side: resp depression, itching

Question 1

5 families of opioid receptors

Answer 1

mu
kappa
sigma
delta
epsilon

Question 2

Fentanyl/ Duragesic

Answer 2

opioid analgesic that’s like morphine x80
used for anesthesia and intractable pain
comes in a lollypop form
side: respiratory depression -> hypoventilation
constipation, addiction

Question 3

codeine

Answer 3

weaker opioid analgesic that can cause sedation or constipation

Question 4

Tramadol/Ultram

Answer 4

Centrally acting analgesic
more reuptake of nore and serotonin
less respiratory depression than others

Question 5

Naloxone/ Narcan

Answer 5

opioid antagonist that antidotes opioid overdose

it binds to the opioid receptors without eliciting the response

Question 6

Aspirin/ Acetylsalicylic acid

Answer 6

NSAID
irreversible cox1 and 2 inhibition.
blocks prostaglandins @ thermoregulatory centers-> anti-pyretic
decreases tissue sensitivity to the sensation of pain
sides: GI, REYES!!!, SALICYLISM,

Question 7

All cox inhibitors can cause these side effects:

Answer 7

renal dz

elevated bp

Question 8

Salicylism sxs

Answer 8

dizziness, tinnitus, hyperventilation, coma, death

Question 9

Celecoxib/ Celebrex

Answer 9

NSAID that does reversible, selective COX2 inhibition

Question 10

Acetaminophen/ Tylenol

Answer 10

NSAID-
Sides:
overdose with alcohol-> hepatic necrosis -> metabolized to NAPQI usually just excreted but excess leads to hepatocellular death
Category B

Question 11

Acetominophen poisoning

Answer 11

stage 1 (12-24 hrs)- n/v 
Stage 2 (24-48 hrs)- increasing liver enzymes
stage 3 (72-96 hrs)- peak hepatotoxicity
stage 4 - recover, or have liver transplant or death

NAC for antidote to augment glutathione reserves