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gold usmle: CNS pharm Flashcards

1
Q

“TOM”

A

Short –acting BDZs:

  1. Triazolam
  2. Onazelam
  3. Midazolam
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2
Q

Butyrophenone

A

Haloperidol & Droperidol

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3
Q

Atypical D4

A

Clozapine – Thioridazine – Olanzepine – Risperidone = Do not cause EPS

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4
Q

Flumazenil

A

BDZ antidote for OD

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5
Q

Methylphenidate

A

Txt attention deficit disorder

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6
Q

Phenytoin

A

Causes aplastic anemia/ gingival hyperplasia/ cleft lip & palate

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7
Q

Thiopental

A

Short acting Barb

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8
Q

Carbamazepine

A

DOC trigeminal neuralgia. Txt lennox gestaut seizures in kids

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9
Q

Atypical D4-r

A

Thioridazine; Olamzapine; Clozapine

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10
Q

Pimozide

A

Txt Tourette’s

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11
Q

Risperidone

A

Good for negative symptoms

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12
Q

Thioridazine

A

Most anti cholinergic neuroleptic

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13
Q

Haloperidol

A

Neuroleptic malignant hyperthermia due to chronic D2 block. give Dantrolene and Bromocriptine

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14
Q

Imirpamine

A

Enurisis

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15
Q

Clomirpramine

A

Txt OCD See aggressive behavior w/ use

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16
Q

Trazadone

A
  1. Priapism
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17
Q

Bupropion

A

Helps to quit smoking

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18
Q

SSRIs

A

Primarily used for OCD

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19
Q

Fluoxetine

A

Good for negative symptoms

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20
Q

Phenelzine

A

Irreversible MAOI

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21
Q

Lithium

A

Txt manic phase of Bipolar Disorder

  1. Causes goiter by (-) conversion of T4 to T3
  2. Nephrogenic diabetes insipidus
  3. Low salt diet will lead to Li toxicity
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22
Q

Alprazolam

A

DOC stage fright

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23
Q

Propranolol

A

Social phobia

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24
Q

κ-r

A

Spinal analgesia. Euphoria. ++euphoria. ++sedation. Constipation.

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25
Q

μ-r

A

Supraspinal analgesia. Dysphoria. +respiratory depression. +sedation.

26
Q

Morphine & O2

A

Admin. is contraindicated to pts on morphine sedation= ↓ CO2 sensitivity and O2 admin. can stop breathing.

27
Q

Morphine

A

↑ ICP = do not give to pt. with head trauma

28
Q

Morphine OD

A

1.pinpoint pupils 2.↓’d respiraiton 3.coma

29
Q

Meperidine

A

Anesthetic used during labor

30
Q

Hydromorphone

A

μ(+) used in renal failure

31
Q

Tramadol

A

Ambulatory txt for mod. to severe pain

32
Q

Naloxone

A

Txt opioid OD. Reverses respiratory depression

33
Q

Pentazocine

A

Part κ(+) & part μ(-)

34
Q

Butorphenol

A

Part κ(+) & part μ(-)

35
Q

Nalbuphene

A

Part κ(+) & part μ(-)

36
Q

↓ GABA

A

↓ seizure focus= Barbs & BDZs

37
Q

↓ Fast Na Ch.

A

↓ electrical activity spread = Phenytoin & Carbamazepine

38
Q

Methoxyflurane

A

Can be nephrotoxic. Needs low MAC for anesthetic induction.

39
Q

Enflurane

A

Can cause tonic/clonic muscle spasms

40
Q

Isoflurane

A

Can cause bronchospasm

41
Q

Halothane

A

Can cause ventricular extrasystoles & Malignant hyperthermia & Hepatitis

42
Q

Nitric Oxide

A

No effect on HR. Needs high MAC for anesthetic induction.

43
Q

Thiopental

A

Short acting Barb.

44
Q

Ketamine

A

Dissociative anesthetic

45
Q

Droperidol

A

Can be used in combo w/ Fentanyl for neuroleptoanalgesic effect
52. Neuroleptic tranquilizer. Has mild alpha block

46
Q

Fentanyl

A

Can be used on combo w/ Droperidol for neuroleptoanalgesic effect
54. Used transdermally for chronic pain

47
Q

Midazolam

A

Pre anesthetic. Induces amnesia

48
Q

Primidone

A

Biotransformed to Phenobarb.

49
Q

C & A delta Fibers

A

First fibers to be blocked w/ anesthesia

50
Q

Esters

A

Procaine, Tetracaine, Benzocaine

59. Broken down and make PABA (allergen)

51
Q

Amides

A

Lidocaine, Mepivaciane, Bupivaciane, Etidocaine= “i” before “caine” always an amide
61. Metabolized in the liver

52
Q

Amphetamine

A

DA reuptake (-)’r. MAOI. Parkinson’s txt

53
Q

Bromocriptine

A

D2(+). Used w/ L-Dopa for “on-off” phenomenon of Parkinson’s

54
Q

Benztropine

A

Ant M w/ some DA reuptake (-). Parkinson’s txt

55
Q

Amantidine

A

↓ DA reuptake. Can cause livido reticularis= skin mottling.

56
Q

Diphenhydramine

A

Txt early Parkinson’s stages

57
Q

Pergolide

A

> Effective & longer acting than Bromocriptine

58
Q

Ethosuximide

A

DOC for Absence seizures

59
Q

Tranylcypromine

A

. MAOI = antidepressant

reversible inhibitor

60
Q

SSRI & MAOI

A

Fatal combo, especially seen with the use of Paroxetine or Fluoxetine (SSRIs) and Tranylcypromine (MAOI)

61
Q

Labor opioids

A

Meperidine & Nalbuphine

62
Q

Desipramine causes

A

Sudden cardaic death in children

neuro (18 decks)

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