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neuro > gold usmle: anti-neoplastic pharm > Flashcards

gold usmle: anti-neoplastic pharm Flashcards

1
Q

Cyclosporine

A

Protects against rejections from organ transplants

81. Does not induce bone marrow depression

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2
Q

Cyclophosphamide

A

Alkylating agent of both purine & pyrimidine bases of DNA
83. Txt CLL

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3
Q

Cisplatin’s toxicities

A

Nephro- & Ototoxicity

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4
Q

Methotrexate

A

Antimetabolite of folic acid: (-)dihydrofolate reductase

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5
Q

Leucovorin Rescue

A

Can block/reduce Methotrexate = ↑ folic acid via a reduced folate

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6
Q

Bleomycin toxicities

A

Pneumonitis & pulmonary fibrosis

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7
Q

Azathiorine

A

Used in organ transplantation = kidney allografts

89. Allopurinol can ↑ its activity by (-) its biotransformation to xanthine oxidase

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8
Q

MOPP

A

Chemotherapy used in the txt of Hodgkin’s disease

  1. M = Mechlorethamine – nitrogen mustard
  2. O = Oncovin (Vincristine) – prevents microtubule assembly
  3. P = Procarbazine
  4. P = Prednisone – glucocorticoid, inducing apoptosis
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9
Q

Tamoxifen

A

(-) estrogen receptor

96. Txt of breast tumors, can see associated endometrial CA

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10
Q

Flutamide

A

Antiandrogenic

  1. Used w/ Leuprolide (LH-RH analog)
  2. Txt prostatic CA
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11
Q

Megestrol

A

(-) progesterone receptor

101. Txt endometrial CA

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12
Q

Fluoxymesterone

A

Androgenic steroid

103. Txt mammary CA in postmenopausal women

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13
Q

Methotrexate

A

Folic acid analog that (-) tetrahydrofolate synthesis by (-) dihydrofolate reductase

  1. Txt of ALL
  2. Txt of Psoriasis
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14
Q

Brain tumor Txt

A

Lomustine

108. Carmustine – Causes pulmonary fibrosis

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15
Q

Streptozocin

A

Attaches to β cells

110. Txt of pancreatic insulinomas

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16
Q

Cytarabine (AraC)

A

Pyrimidine analog

112. DOC for AML

17
Q

Dactinomycin

A

Used for Wilms tumor & rhabdomyosarcoma

18
Q

Etoposide

A

Used for oat cell CA

19
Q

Paclitaxel

A

Used for ovarian CA

20
Q

Amifostine

A

Can ↓ nephrotoxicity due to chronic use of Cisplatin

neuro (18 decks)

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