GI12

Question 1

What are Peyer’s patches?

Answer 1

Unencapsulated lymphoid tissue

*Contain specialized M cells that take up Ag

Question 2

Where are Peyer’s patches found?

Answer 2

Lamina Propria and Submucosa of ILEUM

Question 3

What happens to B cells that are stimulated in the Germinal Centers of Peyer’s patches?

Answer 3

Differentiate into IgA-secreting plasma cells

*Reside in Lamina Propria

Question 4

What antibody deals with intraluminal gut antigens?

Answer 4

IgA

“think of IgA, the Intra-Gut Antibody”

*Always say “secretory IgA”

Question 5

What is Bile composed of?

Answer 5

Bile salts 
Phospholipids
Cholesterol
Bilirubin
Water
Ions

Question 6

What are Bile salts?

Answer 6

Bile acids conjugated to Glycine or Taurine

*makes them water Soluble

Question 7

What is the rate-limiting enzyme in Bile?

Answer 7

Cholesterol 7a-hyodroxylase

Question 8

What is the function of Bile?

Answer 8

• Digestion and absorption of lipids and fat-soluble vitamins
• Cholesterol excretion (body’s only means of eliminating cholesterol)
• Antimicrobial activity (via membrane disruption)

Question 9

What is Bilirubin the product of?

Answer 9

Heme metabolism

Question 10

What enzyme makes Conjugated bilirubin (DIRECT)?

Answer 10

UDP-glucuronosyl-transferase

*adds Glucuronic acid