GI Motility Flashcards
the trade off for the efficiency of smooth vs. skeletal muscle is
speed of contractions
what part of GI does phasic contractions
antral stomach
SI
large intestine
what part of GI does tonic contractions
sphincters
what is tonus
maintained state of partial contraction
what does BER stand for
basic electric rhythm
oscillating membrane potential is called
slow waves or BER
what is another name for BER
slow waves
what does BER do
sets pace for contractions
slow waves are initiated by
pacemaker cells
what is the name of the pacemaker cell of GI
Interstitial cells of Cajal (ICC
what does ICC stand for
Interstitial cells of Cajal
how many waves per min for stomach
3
how many waves per min for SI
11-12
how many waves per min for large intestine
2-13
hormones can change what regarding contractions
amplitude but not frequency
if there is no extrinsic innervation, GI muscles contract in response to
stretch
electrical slow waves in SI are always
present
even without AP, smooth muscle is not completely relaxed in SI, it exhibits
tonic contraction
if there is action potential on top of slow waves, what happens
phasic contraction
the greater the number of AP on top of slow wave, the
larger the phasic contraction
describe twitches of smooth muscle compared to skeletal
in smooth there are not separate twitches, the twitches summate to one long contraction
AP are generated in response to
neural stimulation
hormonal stimulation
stretching the muscle
what does Ach do to GI
increase strength of contraction by increasing Ca2+ in cells
how does Ach increase strength of contraction
by increasing Ca2+ in cells
what does NE do to GI
inhibits contraction
where are ICC found
stomach
proximal duodenum
mid colon
what set the rate of BER
ICC
how do ICC set rate of BER
gap junction coupling
what are the two motility patterns the enteric NS encodes
segmental & peristaltic
when is the segmental pattern dominant
after eating
what does post-prandial mean
after a meal
when is the peristaltic pattern dominant
fasting
what part of GI does central nervous system have total control
proximal esophagus & anus
what part of GI does central nervous system have partial control
distal esophagus, stomach, and colon
what part of GI does central nervous system have almost no control
SI
what is the major mode of unidirectional propulsion
peristalsis
what contraction type promotes mixing and can limit transit
segmental (rhythmic) contraction
what is another name for segmental contraction
rhythmic
what kind of contractions block transit
tonic
draw out the sphicnters
pg 12
how are sphincters contracted
tonically
describe control of swallowing
initially voluntary but becomes involuntary
what are the three phases involved in swallowing
oral
pharyngeal
esophageal
describe the oral phase
initiated voluntarily by the movement of food to the back of the mouth
describe the pharyngeal phase
reflexive and peristaltic
describe the esophageal phase
slower and peristaltic
what coordinates the involuntary swallowing process
swallowing center in medulla
what kind of receptors are in swallowing center
Somatosensory receptors in the pharynx stimulate the swallowing center in the medulla
what is inhibited in pharyngeal phase
breathing
what covers larynx opening in pharyngeal phase
Epiglottis
what is purpose of epiglottis covering larynx
prevents food from going into trachea
in esophageal phase, bolus is moved down esophageus by
perimary peristaltic wave
if primary peristaltic wave does not clear esophagus, what happens
secondary peristaltic wave
what controls esophageal phase
partly reflexive and partly ENS
1 second of stimulation for initiation of swallowing leads to
9 seconds of programmed muscle contraction
list the steps of esophagus reflex
pg 15
when a person isn’t swallowing what is happening with esophageal sphincter
contracted
when a person isn’t swallowing what is happening with glottis
open
when person isn’t swallowing what is happening with epiglottis
up
when is swallowing reflex triggered
when bolus of food reaches the pharynx
how does body prevent food from entering trachea
larynx moves up and tips epiglottis over glottis
calcium activated potassium channel will produce
repolarization
what kind of receptors in back of throat
tactile receptors
draw out the vagus nerve and it’s innervation in the esophageal phase
pg 18
what is the only esophageal motility pattern
peristalsis
does esophageal muscle have spontaneous contraction
no
draw out the peristalsis of esophageal in regards to what is relaxing and what is contracting as a bolus travels
pg 19
draw out the peristalsis mechanism, specifically with the inhibitory interneuron and the excitatory interneuron
pg 20
what is the purpose of swallowing manometry
can see if peristalsis is behaving correctly
how is the LES different from the UES?
LES has thick band of muscle and will form vestibule (pocket) so acid doesn’t leak out
LES is innervated by
vagal excitatory fibers
vagal inhibitory fibers
relaxation of LES is associated with what happening in its innervation
increased frequency of AP for vagal inhibitory fibers
decreased frequency of AP for vagal excitatory fibers
what portion of stomach must relax to accept food bolus
orad
what are the three anatomic regions of the stomach
fundus
body
antrum
what does fundus do during feeding
relaxes
the fundus relaxes during feeding, this is called
receptive relaxation/accomodation
what is the orad portion of the stomach
thin walled, receives food bolus through receptive relaxation
the stomach can accomodate large volumes without change in
pressure
receptive relxation is what kind of reflex
vagovagal
vagovagal reflex in stomach is elicited by
stretching of the stomach
what does CCK do to the orad area
makes it more distendible
what is the caudad portion of the stomach
thick walled, produces contractions
where does contraction begin in the stomach
middle of body through caudad
what is Retropulsion
Not all chyme goes into duodenum as contractions also close pylorus propelling contents back into stomach for further mixing and reduction
what is function of pyloric sphincter
sieves material, prevents particles that are too big (more than 1 mm) from leaving stomach
prevents reflux of duodenal material
what 2 major factors slow or inhibit gastric emptying
Fat & H+ in duodenum
effects of fat is mediated by
CCK
if there is too much H+ in stomach what happens
deteced by ENS
slows gastric smooth muscle
permits more time for HCO3- to neutralize
before a solid meal can be emptied from the stomach, there is what phase
lag phase
what is the lag phase
allows time for the food to be reduced to small enough size to enter SI
PNS increases contraction of SI through what 4 neuropeptides
ACh, Substance P, enkephalins, motilin
what are the two patterns of contraction in the SI
segmentation & peristaltic
what is quiescent contraction
no contraction
what are the phases of fasting motility pattern
I: quiescent
II: random contractions
III: migrating myoelectric complex
what does MMC stand for
migrating myoelectric complex
phase III/MMC is correlated with rise in levels of what hormone
motilin
how long does it take MMC to move down SI
90 min
what is the fed motility pattern
irregular spikes from meals → segmental contractions mixed with short perstalic waves
what is the function of segmented contraction
mixes food and exposes it to all the “juices”
what happens when intestines contract in segmented contraction in SI
bolus of food is split in orad and caudad directions
what happens when intestins relax in segmented contraction in SI
the split bolus merges back together
what is the function of peristalic contraction in SI
propels chyme along SI to LI
what neurotransmitters are involved in orad contraction
ACh & Substance P
what neurotransmitters are involved in caudad relxation
VIP
NO
peristalic reflex of SI depends on what nervous system
enteric
intestinointestinal reflex depends on what nervous system
extrinsic
what is purpose of Intestinointestinal reflex
Severe distention in one area inhibits contractions in the remaining bowel.
describe the peristaltic reflex in SI
Distention of the SI causes contraction above and relaxation below distension.
describe the Gastroileal reflex in SI
Movement of ileal contents into large intestine is stimulated by the presence of food in the stomach
emesis =
vomitting
prlonged vomitting can result in
alkalosis, hypokalemia, and dehydration.
retching =
dry heaving
in dry heaving, what happens regarding UES & LES
LES open
UES closed
what are the main anatomical regions of LI
ascending, transverse, descending, sigmoid colon and the rectum
what kind of contractions occur in cecum and proximal colon of LI
segmentation contractions
movements in colon are coordinated by
BER
describe segmented contraction in LI
occur in cecum and proximal colon: mixes contents; are associated with sac-like segments called haustra. Fibers in external muscle layer form outpouchings.
the colon is divided into segments called
haustra
b/w haustral pockets there are
segments of contracted circular muscle
what do inhibitory neurons do regarding haustra
they maintain the relxation in the haustra/pockets
segmented contractions in LI facilitate
absorption
describe the Colonocolonic reflex
Distention of one part of the colon elicits reflex relaxation in other parts of the colon → partly mediated by the sympathetic fibers
describe the Gastrocolic reflex
The motility of proximal and distal colon and the frequency of mass movements increase after a meal enters the stomach.
colonocolic reflex is mediated by
sympathetic fibers
the gastrocolic reflex is mediated by
CCK & gastrin
Rectosphincteric reflex is also called
defecation reflex
describe the Rectosphincteric reflex
As rectum fills with feces, smooth muscle wall contracts in the rectum and internal anal sphincter relaxes – no defecation as external anal sphincter tonically contracted
when do you get the urge to defecate
when the rectum is filled to 25% of its capacity
what does the Valsalva maneuver do
increase intra-abdominal pressure
what does CCK do to gastric emptyin
inhibits
describe the defecation reflex
pg 41
during mass movement of colon what happens
segmentation stops and haustra disappear, peristaltic contractions move material from one section to another
why does H+ slow down gastric emptying
too much hydrogen means digestive enzymes wont work need bicarb.
compare gastric emptying depending on composition of meal
solid goes much slower than semisolid which goes slower than liquid
after 60 min how much of solid meal is still in stomach
60%
if there is semisolid meal how much is still in stomach after 60 min
40%
if there is liquid meal how much is in stomach after 60 min
10%
what is lag phase?
secretions
mechanical breakdown
is there lag phase for liquid
no
MMC starts where
antrum of stomach
MMC cycle is how long
90 min
what is major pattern after meal
rhythmic segmentation
how does segmentation contraction work
contract right in the middle of the food bolus until its small enough to move forward
contracting in peristaltic contraction via
Ach
Substace P
relaxing in peristaltic contraction via
VIP
NO