GI Drugs Flashcards
Cell responsible for the secretion of H+ and Intrinsic factors in the stomach?
Parietal/ Oxyntic cells
Oxyphil - parathyroid
Mucus neck cells?
HCO3
micarmomate
G cells?
Gastrin
Chief/ Zymogenic cells?
Pepsinogen
chief ng pep squad
Entero-Chromaffin Like cell?
Histamine
Stimuli of H+/K+ ATPase (3)
ACH - M3
H2 - H2 Receptor
Gastrin
Antacids capable of being absorbed in the stomach?
Sodium bicarb
Calcium bicarb
pHGoals
3= healing ulcer 4= stress ulcer 6= bleeding ulcer
H2 antagonist - ring
cIMEtidine - imidazole
RANitidine - fuRan
NniZAtidine, fAmotidine - Thiazole
cross placenta, not teratogenic, rapid hepatic metab
H2 antagonist w/ endocrine side effects?
Cimetidine
Same as ketoconazole
Aripripazole is nor a PPI, but a ?
Antipsychotic
MOA of PPI?
Irreversibly block the PP- 18-24 hours for parietal cell to make PP
SHORT half life
All PPIs are prodrug. Converted in the intestines but destroyed by gastric acid. So dosage form is?
ENTERIC COATED
PPIs arrangement based on bioavailability?
L-PERO Lantoprazole Pantoprazole Esomeprazole Rabeprazole Omeprazole
All PPIs are renally excreted except?
Lantoprazole - Biliary
GI Bleeding sign.
80mg/IV bolus then constant infusion 8mg/hour
Omeprazole interacts w/ ?
Clopidogrel
PPI affect absorption of ? ? ? ?
B12
Fe
Ca
Zinc