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Pharmacology > GI Drugs > Flashcards

GI Drugs Flashcards

1
Q

Cell responsible for the secretion of H+ and Intrinsic factors in the stomach?

A

Parietal/ Oxyntic cells

Oxyphil - parathyroid

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2
Q

Mucus neck cells?

A

HCO3

micarmomate

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3
Q

G cells?

A

Gastrin

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4
Q

Chief/ Zymogenic cells?

A

Pepsinogen

chief ng pep squad

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5
Q

Entero-Chromaffin Like cell?

A

Histamine

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6
Q

Stimuli of H+/K+ ATPase (3)

A

ACH - M3
H2 - H2 Receptor
Gastrin

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7
Q

Antacids capable of being absorbed in the stomach?

A

Sodium bicarb

Calcium bicarb

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8
Q

pHGoals

A 
3= healing ulcer
4= stress ulcer
6= bleeding ulcer
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9
Q

H2 antagonist - ring

A

cIMEtidine - imidazole
RANitidine - fuRan
NniZAtidine, fAmotidine - Thiazole

cross placenta, not teratogenic, rapid hepatic metab

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10
Q

H2 antagonist w/ endocrine side effects?

A

Cimetidine

Same as ketoconazole

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11
Q

Aripripazole is nor a PPI, but a ?

A

Antipsychotic

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12
Q

MOA of PPI?

A

Irreversibly block the PP- 18-24 hours for parietal cell to make PP

SHORT half life

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13
Q

All PPIs are prodrug. Converted in the intestines but destroyed by gastric acid. So dosage form is?

A

ENTERIC COATED

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14
Q

PPIs arrangement based on bioavailability?

A 
L-PERO
Lantoprazole
Pantoprazole
Esomeprazole
Rabeprazole
Omeprazole
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15
Q

All PPIs are renally excreted except?

A

Lantoprazole - Biliary

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16
Q

GI Bleeding sign.

A

80mg/IV bolus then constant infusion 8mg/hour

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17
Q

Omeprazole interacts w/ ?

A

Clopidogrel

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18
Q

PPI affect absorption of ? ? ? ?

A

B12
Fe
Ca
Zinc

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19
Q

PGE analogue that inc. mucus/HCO3

A

Misoprostol

20
Q

All prostaglandins are vasoconstrictors except ? and ?

A

PGE
PGI

All mcdonalds had a farm E I EI O vasodilator

21
Q

Which of the ff. mucosal protective have anti-microbial effects?

A

Bismuth salts

22
Q

ADR of Bismuth Salt?

A

Blackening of the stool and gums

23
Q

Factors that increase gastric motility? (3)

A

GAM
Gastrin
ACH
Motilin

24
Q

Which of the ff. increase BOTH acid sec. and gastric motility? (2)

A

Gastrin

ACH

25
Q

Dopamine _____ motility

A

INHIBITS

D gagalaw

26
Q

Dopamine is also known as?

A

Prolactin inhibitory hormone

27
Q

Metoclopramide is a D2 antagonist and has this endocrine side effect?

A

Hyperprolactinemia = Galactorrhea

Tx: Dopamine agonist like BROMOCRIPTINE

28
Q

D2 antagonist that doesn’t cross the BBB and is for post partum lactation?

A

Domperidone

29
Q

MOA of Erythromycin for being prokinetic agent?

A

promotes MOTILIN RELEASE

30
Q

CIs of laxatives?

A

ACUTE abdominal disorders
Appendicitis
Diverticulitis
Ulcerative Colitis

why? risk of bowel rupture sis

31
Q

Bulk Forming Laxatives

A

Methylcellulose
Psyllium
Polycarbophil

32
Q

MOA of Bulk Forming

A

absorbs water
soften and enlarge stool
fecal swelling -> peristalsis

33
Q

Only laxative that can be used chronically?

A

BULK forming

34
Q

Osmotic laxatives

A

Magnesium hydroxid (Millk of Magnesia)
Lactulose, sorbitol
Glycerin (suppository)

35
Q

Surfactant laxatives/ Emollient/ Stool softners MOA?

A

Lowers surface tension -> facilitates water penetration

Ex. DOCUSATE SALTS

36
Q

Stimulant Laxatives ex.

A

Phenopthalein
Bisacodyl

MOA: Stimulates peristalsis

37
Q

Lubricant Laxatives MOA?

A

Interferes with H20 and fat absorption

Ex. MINERAL OIL

38
Q

MOA of Simethicone?

A

Breaks gas bubbles = antiflatulence

39
Q

Agent for whole bowel irrigation? (bowel evacuant)

A

Polyethylene glycol

40
Q

MOA of 5-ASA/ Mesalamine for IBD

A

Inhibits synthesis of PGs and inflam. leukotrienes

41
Q

5-ASA/ Mesalanin is a __ therapy for IBs

A

topical - pinapahid sa mucosal surface

42
Q

A 5-ASA that can cause SJS?

A

Sulfasalazine

43
Q

5-ASA for Jejunum-Rectum

44
Q

5-ASA for the colon only? (2)

A

Sulfasalazine
Balsalazide

Ulcerative colitis

45
Q

5-ASA for Ileum-Rectum

A

Asacol

Lialda

46
Q

5-ASA for Sigmoid-rectum?

47
Q

5-ASA for Rectum?

Pharmacology (13 decks)

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