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Pharmacology > Anti-Virals > Flashcards

Anti-Virals Flashcards

1
Q

Enveloped virus will be released via?

A

Exocytosis

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2
Q

Naked virus will be released via?

A

Cell lysis

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3
Q

6 steps of DNA virus attacking host cell

A 
Attachment
Uncoating
Nuclear entry (only in DNA)
Replication
Assembly
Release
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4
Q

HIV receptors (3)

A

CD4
CXCR4
CCR5

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5
Q

CMV receptor

A

Integrins (Heparan sulfate)

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6
Q

EBV receptor

A

CD21

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7
Q

Anti-influenza 2 classifications?

A

M2 inhibitors

Neuraminidase (NA) inhibitors

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8
Q

Influenza receptors involved in mutations (2)

A

AH1N1
Hemaglutinin
Neuraminidase

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9
Q

M2 inhibitors/ M2 protein ion channel inhibitors (2)

A

Amantadine
Rimantadine

(-) coating!!!

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10
Q

Neuraminidase inhibitors (2)

A

Zanamivir
Oseltamivir (Tamiflu)

(-) release

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11
Q

ADR in M2 inhibitors

A

Livedo Reticularis

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12
Q

Amantadine and Rimantadine (M2 inh.) is for Influenza?

A

Influenza A only

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13
Q

M2 inhibitor that can inc. dopamine => Parkinson’s dse

A

Amantadine

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14
Q

Neuraminidase inhibitor is for Influenza?

A

Influenza A and B

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15
Q

Which of the ff. anti-virals use viral enzyme for their activation?

A
  • cyclovirs
    Acyclovir
    Penciclovir
    Gangciclovir

Uses: thymidine kinase (viral enzyme)
I: For herpes

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16
Q

MOA of all-anti herpes drugs

A

(-) Viral DNA polymerase

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17
Q

Which of the anti-virals uses host enzymes?

A

Trifluridine
Cidofovir

I: For herpres

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18
Q

Tx for Herpes-Zoster (Shingles)

A

Famcyclovir

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19
Q

ADR of Acyclovir

A

Crystal-induced kidney injury; Crystalluria

20
Q

DOC for CMV

A

Ganciclovir

ADR: Pancytopenia

21
Q

DOC for Ganciclovir-resistant CMV

A

Foscarnet

22
Q

Drugs for Acyclovir-resistant HSV (2)

A

Foscarnet

Cidofovir

23
Q

Class of dugs for Hep B (2)

A
  1. Nucleoside/ Nucleotide Reverse Transcriptase Inhibitors(NRTIs)
  2. Non-Nucleoside/ Nucleotide Reverse Transcriptase Inhibitors(NRTIs)
24
Q

NNRTIs (3)

A

END w/ vi in the middle

EfaVIrenz
NeVIrapine
DelaVIrdine

25
Q

NRTIs

A

abaca ni dida em may lamb, stars, tenor si Adel, at ziDove

ABACAvir
DIDAnosine
EMtricitabine
LAMivudine
STAvudine
TENOfovir
ZIDOVudine
ADEfovir
26
Q

All NRTIs will need phosphorylation except?

A

Tenofovir

27
Q

NRTIs: Active site of reverse transcriptase
NNRTIs: ?

A

Allosteric site of reverse transcriptase

28
Q

ADR of Tenovovir and Adefovir

A

Fanconi’s syndrome (GAP)

Glycosuria
Amino aciduria
Phosphaturia

Also seen in Tetracycline

29
Q

Drug for Hep C

A

Ribavirin

30
Q

MOA of Ribavirin, a drug for Hep C

A

Guanosine analogue
Inhibits IMP dehydrogenase
prevents synthesis of guanine nucleoside
no DNA synthesis

31
Q

ADR of Ribavirin

A

Hemolytic Anemia

32
Q

Aside from Hep C, Ribavirin is also used in

A

RSV bronchiolitis

33
Q

Drug for acute Hepa C and Chronic Hepa B

A

As monotherapy:
Pegylated interferon-alpha - improves pharmacokinetics (ADME)
Interferon-alpha

34
Q

MOA and ADR of Pegylated interferon alpha and interferon alpha

A

Immunomodulation

Bone Marrow Suppression

35
Q

Pegylated interferon-alpha/ and interferon -alpha is used in combination when treating

A

Chronic Hepa C

36
Q

An ART which inhibits CCR5 receptor?

A

5 - V

MaraViroc - CC5 antagonist

37
Q

An ART which inhibits fusion?

A

Fu fu

EnFUrtivide - Fusion inhibitor

38
Q

An ART which inhibits integrase?

A

-teg-

Raltegravir
Doultegravir

39
Q

An ART which inhibits protease which will then inhibit viral release?

A

Protease inhibitors, mga friends mong hindi navir =)))
-navir-

Lopiravir
Ritonavir
Indinavir
Nelfinavir
Sequenavir
40
Q

ADR of Stavudine (NRTI)

A

Non-alcoholic steato hepatitis (NASH)

41
Q

ADR of Zidovidine (NRTI)

A

Bone Marrow Suppression - like pegylated interferon alpha

42
Q

ADR of Abacavir (NRTI)

A

Anaphylaxis

43
Q

ADR of Didanosine (NRTI)

A

Pancreatitis - si daryl nag ka pancreatitis hahahaha

44
Q

ADR of Efavirenz (NNRTI)

A

Teratogenecity; Seizures/ Enceph

45
Q

ADR of Protease inhibitors (navir)

A

Hyper GUL
Glycemia
Uremia
Lipidemia

parang diuretics

46
Q

Recommended regimen for HAART?

A

3 NRTI

2 NRTI + 1 NNRTI/ 1 PI/ 1 INI

47
Q

DOC for Chronic Hep B?

A

Lamivudine/ IgG/ Interferon alpha

Pharmacology (13 decks)

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