Anti-Virals

Question 1

Enveloped virus will be released via?

Answer 1

Exocytosis

Question 2

Naked virus will be released via?

Answer 2

Cell lysis

Question 3

6 steps of DNA virus attacking host cell

Answer 3

Attachment
Uncoating
Nuclear entry (only in DNA)
Replication
Assembly
Release

Question 4

HIV receptors (3)

Answer 4

CD4
CXCR4
CCR5

Question 5

CMV receptor

Answer 5

Integrins (Heparan sulfate)

Question 6

EBV receptor

Answer 6

CD21

Question 7

Anti-influenza 2 classifications?

Answer 7

M2 inhibitors

Neuraminidase (NA) inhibitors

Question 8

Influenza receptors involved in mutations (2)

Answer 8

AH1N1
Hemaglutinin
Neuraminidase

Question 9

M2 inhibitors/ M2 protein ion channel inhibitors (2)

Answer 9

Amantadine
Rimantadine

(-) coating!!!

Question 10

Neuraminidase inhibitors (2)

Answer 10

Zanamivir
Oseltamivir (Tamiflu)

(-) release

Question 11

ADR in M2 inhibitors

Answer 11

Livedo Reticularis

Question 12

Amantadine and Rimantadine (M2 inh.) is for Influenza?

Answer 12

Influenza A only

Question 13

M2 inhibitor that can inc. dopamine => Parkinson’s dse

Answer 13

Amantadine

Question 14

Neuraminidase inhibitor is for Influenza?

Answer 14

Influenza A and B

Question 15

Which of the ff. anti-virals use viral enzyme for their activation?

Answer 15

• cyclovirs
  Acyclovir
  Penciclovir
  Gangciclovir

Uses: thymidine kinase (viral enzyme)
I: For herpes

Question 16

MOA of all-anti herpes drugs

Answer 16

(-) Viral DNA polymerase

Question 17

Which of the anti-virals uses host enzymes?

Answer 17

Trifluridine
Cidofovir

I: For herpres

Question 18

Tx for Herpes-Zoster (Shingles)

Answer 18

Famcyclovir

Question 19

ADR of Acyclovir

Answer 19

Crystal-induced kidney injury; Crystalluria

Question 20

DOC for CMV

Answer 20

Ganciclovir

ADR: Pancytopenia

Question 21

DOC for Ganciclovir-resistant CMV

Answer 21

Foscarnet

Question 22

Drugs for Acyclovir-resistant HSV (2)

Answer 22

Foscarnet

Cidofovir

Question 23

Class of dugs for Hep B (2)

Answer 23

1. Nucleoside/ Nucleotide Reverse Transcriptase Inhibitors(NRTIs)
2. Non-Nucleoside/ Nucleotide Reverse Transcriptase Inhibitors(NRTIs)

Question 24

NNRTIs (3)

Answer 24

END w/ vi in the middle

EfaVIrenz
NeVIrapine
DelaVIrdine

Question 25

NRTIs

Answer 25

abaca ni dida em may lamb, stars, tenor si Adel, at ziDove ``` ABACAvir DIDAnosine EMtricitabine LAMivudine STAvudine TENOfovir ZIDOVudine ADEfovir ```

Question 26

All NRTIs will need phosphorylation except?

Answer 26

Tenofovir

Question 27

NRTIs: Active site of reverse transcriptase NNRTIs: ?

Answer 27

Allosteric site of reverse transcriptase

Question 28

ADR of Tenovovir and Adefovir

Answer 28

Fanconi's syndrome (GAP) Glycosuria Amino aciduria Phosphaturia Also seen in Tetracycline

Question 29

Drug for Hep C

Answer 29

Ribavirin

Question 30

MOA of Ribavirin, a drug for Hep C

Answer 30

Guanosine analogue Inhibits IMP dehydrogenase prevents synthesis of guanine nucleoside no DNA synthesis

Question 31

ADR of Ribavirin

Answer 31

Hemolytic Anemia

Question 32

Aside from Hep C, Ribavirin is also used in

Answer 32

RSV bronchiolitis

Question 33

Drug for acute Hepa C and Chronic Hepa B

Answer 33

As monotherapy: Pegylated interferon-alpha - improves pharmacokinetics (ADME) Interferon-alpha

Question 34

MOA and ADR of Pegylated interferon alpha and interferon alpha

Answer 34

Immunomodulation | Bone Marrow Suppression

Question 35

Pegylated interferon-alpha/ and interferon -alpha is used in combination when treating

Answer 35

Chronic Hepa C

Question 36

An ART which inhibits CCR5 receptor?

Answer 36

5 - V MaraViroc - CC5 antagonist

Question 37

An ART which inhibits fusion?

Answer 37

Fu fu EnFUrtivide - Fusion inhibitor

Question 38

An ART which inhibits integrase?

Answer 38

-teg- Raltegravir Doultegravir

Question 39

An ART which inhibits protease which will then inhibit viral release?

Answer 39

Protease inhibitors, mga friends mong hindi navir =))) -navir- ``` Lopiravir Ritonavir Indinavir Nelfinavir Sequenavir ```

Question 40

ADR of Stavudine (NRTI)

Answer 40

Non-alcoholic steato hepatitis (NASH)

Question 41

ADR of Zidovidine (NRTI)

Answer 41

Bone Marrow Suppression - like pegylated interferon alpha

Question 42

ADR of Abacavir (NRTI)

Answer 42

Anaphylaxis

Question 43

ADR of Didanosine (NRTI)

Answer 43

Pancreatitis - si daryl nag ka pancreatitis hahahaha

Question 44

ADR of Efavirenz (NNRTI)

Answer 44

Teratogenecity; Seizures/ Enceph

Question 45

ADR of Protease inhibitors (navir)

Answer 45

Hyper GUL Glycemia Uremia Lipidemia parang diuretics

Question 46

Recommended regimen for HAART?

Answer 46

3 NRTI | 2 NRTI + 1 NNRTI/ 1 PI/ 1 INI

Question 47

DOC for Chronic Hep B?

Answer 47

Lamivudine/ IgG/ Interferon alpha