Respi Drugs

Question 1

Objective evidence of Asthma (2)

Answer 1

1. Airflow limitations

2. Variability in lung function

Question 2

Asthma is worst in what time?

Answer 2

Night time and waking hours

Question 3

Test for Airflow limitation

Answer 3

Spirometry

Question 4

Test for Variability in lung function

Answer 4

Bronchodilator Reversibility Test

vs COPD - note reversible

Question 5

(+) bronchodilator reversibility test (2)

Answer 5

1. Inc. in FEV1 of > 12% and >200mL

2. Inc. in PEFR (peak flow meter) >20%

Question 6

Preferred reliever across all steps in Asthma Management

Answer 6

ICS + Formoterol

Most common: Budesonide (Symbicort)

Question 7

The only LABA that can act as a reliever?

Answer 7

Formoterol

Why? LABA but has fast onset

Question 8

SABA

Answer 8

SATURDAY
Salbutamol
Terbutaline

Question 9

1st line for COPD

Answer 9

Muscarinic antagonist/ Anti-cholinergic

Atropium, Ipatropium, Tiotropium, Oxytropium

Question 10

Muscarinic antagonist that has M3 and M2 effect

Answer 10

Ipatropium

Question 11

1-3 methylxanthine

Answer 11

Theophylline

Question 12

3-7 dimethylxanthine

Answer 12

TheoBROmine

mas matanda si bro

Question 13

1,3,7 trimethylxanthine

Answer 13

Caffeine

Question 14

MOA of Methylxanthine

Answer 14

Inhibits phosphodiesterase, non-selective

Question 15

Methylxanthine is both a ? and ?

Answer 15

Reliever and controller

Question 16

MOA of Ketotifen

Answer 16

Mast cell stabilizer/ Chromones

Question 17

Inhibitor of lipooxygenase (LOX) enzyme (inhibition of production of leukotrienes)

Answer 17

Zileuton

Question 18

LTD4 (receptor) antagonists

Answer 18

Montelukast, Zafirlukast

Question 19

Montelukast FDA warning

Answer 19

Nightmare and suicidality

Question 20

Mainstay tx of Bronchial Asthma as controllers

Answer 20

Steroids

Question 21

MOA of Steroids in BA

Answer 21

Inhibit phospholipase A2

Inhibit cytokine release

Question 22

IV steroids

Answer 22

Hydrocortisone

Methylprednisone

Question 23

Inhaled steroids

Answer 23

Budesonide
Bedomethasone
Triamcinolone
Fluticasone
Flunisolide

Question 24

Oral steroids

Answer 24

Prednisone

Prednisolone

Question 25

Glucocoticoid has hydroxyl group at carbon?

Answer 25

11

Question 26

Mineralocorticoid has hydroxyl group at carbon?

Answer 26

21

Question 27

Glucocorticoid has what property?

Answer 27

Anti-inflammatory

Question 28

Mineralocroticoid

Answer 28

Na retaining potency

Question 29

Most potent glucocorticoid/ anti-inflammatory steroids (2)

Answer 29

Dexamethasone

Bethamethasone

Question 30

Most mineralocorticoid/Na retaining potency

Answer 30

Fludrocortisone

Question 31

Short acting steroids

Answer 31

Cor-

Question 32

Long acting steroids

Answer 32

Betha

Dexa