Anti-Inflammatory

Question 1

The first prostaglandin to be produced

Answer 1

PGG

Question 2

Prostaglandins that are vasodilators? (2)

Answer 2

PGE
PGI

E, I, E, I O… vasodilator

Question 3

Activation of EPOX pathway will have ? ? pathology

Answer 3

Cardiac

Renal

Question 4

COX-1 actions

Answer 4

Physiologic COX
Protection of GI mucosa
Platelet agg.
Renal perfusion

Question 5

COX-2 actions

Answer 5

Inducible during injury

Question 6

COX-3 inhibitor

Answer 6

Paracetamol

Question 7

The only irreversible inhibitor of COX?

Answer 7

Aspirin

Question 8

Propionic Acid Derivatives (3)

Answer 8

-Pro

Ibuprofen
Ketoprofen
Fluriprofen

Question 9

Long duration “profen”

Answer 9

Flurbiprofen

Question 10

ADR of Flurbiprofen

Answer 10

Severe gastic irritation

MI

Question 11

All NSAIDS are acidic except ?

Answer 11

Nabumetone

Question 12

NSAIDs used in post-operational therapy as substitute for Morphine

Answer 12

Etodolac

Ketorolac

Question 13

NSAID that is related to sulfonamides

Answer 13

Sulindac

Question 14

NSAID that inhibits PLA2

Answer 14

Indomethacin

Question 15

Tx of PDA

Answer 15

IV Indomethacin

IV Paracetamol

Question 16

When does the PDA close functionally and anatomically

Answer 16

14 hours

14 days

Question 17

Selective COX-inhibitors

Answer 17

-oxib

Celecoxib
Parecoxib
Etoricoxib
Lumiracoxib
Valdecoxib
Rofecoxib

Question 18

Lumiracoxib, Valdecoxib and Rofecoxib were phased out because of?

Answer 18

Thrombosis
MI
HTN

Question 19

MOA of DMARDS

Answer 19

Immunosuppresion

Question 20

MOA of Abatacept

Answer 20

Target CD80, CD86

Batang bata 80, 86

Question 21

MOA of Azathioprine

Answer 21

Converted to 6-thioquanine, inh. DNA synthesis by affecting INOSINIC ACID

Question 22

MOA of Cyclophosphamide

Answer 22

Alkylating agent

Donates alkyl to DNA strand so bibigat si DNA

Question 23

ADR of Cyclophosphamide

Answer 23

HEMORRHAGIC CYSTITIS

Leukopenia

Question 24

Rescue drug for Hemorrhagic Cystitis

Answer 24

MESNA

Question 25

MOA of Cyclosporine

Answer 25

Targets CALCINEURIN

Question 26

ADR of Cyclosporine

Answer 26

Hirsutism (like Minoxidil)
Gingival Hyperplasia (like Phenytoin)

Question 27

ADR of Chloroquine/ Hydroxychloroquine

Answer 27

Ocular toxicity

QT Prolongation

Question 28

MOA of Leflunomide

Answer 28

Inhibits DIHYDROOROTATE DEHYDROGENASE

Question 29

MOA of Methotrexate

Answer 29

Inhibit folate synthesis

Question 30

3 enzymes inhibited by Methotrexate

Answer 30

AICAR transformylase
THYMIDYLATE synthetase
DIHYDROFOLATE reductase

Question 31

Rescue Drug for Methotrexate

Answer 31

Folinic Acid/ Leucovorin

Question 32

MOA of Mycophenolate

Answer 32

Inhibits cytosine mono phosphate (CMP)

Question 33

Metabolite of Sulfasalazine

Answer 33

Sulfapyridine

Question 34

ADR of TNF alpha blockers

Answer 34

Tuberculosis

Question 35

TNF alpha blockers examples

Answer 35

Ertanercept

- mab

Question 36

DOC for acute attack of gout

Answer 36

Colchicine

Question 37

MOA of Colchicine

Answer 37

Inhibit TUBULIN

Question 38

How do you give Colchicine?

Answer 38

500mcg/ 0.5mg 2 tabs now
2 tabs after one hour
2 tabs q12

Question 39

Colchicine is C.I. in px with dialysis, what will you give for acute gout?

Answer 39

1 dose of colchicine and Steroids after

Question 40

MOA of Allopurinol

Answer 40

Xanthine Oxidase inhibitors

Question 41

MOA of Febuxostat

Answer 41

NON-PURINE Xanthine Oxidase inhibitor

Question 42

MOA of Probenecid and Sulfapyrazone

Answer 42

URICOSURIC AGENTS - inhibit reabsorption of uric acid in PCT

Question 43

Probenecid prolongs the action of ______?

Answer 43

Penicillin

bec. it inhibits the active tubular secretion of penicillin

Question 44

Does aspirin cause hyperuricemia?

Answer 44

Yes. Low dose aspirin increases uric acid levels.