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Pharmacology > Antibiotics: Beta Lactam Antibiotics > Flashcards

Antibiotics: Beta Lactam Antibiotics Flashcards

1
Q

Concentration Dependent (QuAA-Met-Dap-Poly)

A 
Quinolones
Aminoglycosides
Azithromycin
Metronidazole
Daptomycin
Polymyxin
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2
Q

The only macrolide that is concentration dependent

A

Azithromycin

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3
Q

Beta-Lactam Inhibitors (PCMC)

A

Penicillin
Cephalosporin
Carbapenem
Monobactams

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4
Q

Penicillin has coverage for anaerobic bacteria EXCEPT

A

Bacteroides Fragilis

- cant give to intraab infection

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5
Q

Penicillins does not have gram negative coverage EXCEPT (3)

A

Neisseria meningitidis (NOT N. gonorrhoeae)
Treponema pallidum
Leptospira spp.

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6
Q

Penicillinase-resistant Penicillins (CONDM)

A 
Cloxacillin
Oxacillin
Naficillin
Dicloxacillin
Methicillin
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7
Q

Methiciliin is off the market due to high incidence of

A

Interstitial Nephritis

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8
Q

What gene is responsible for MRSA

A

Mec A gene

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9
Q

ADR of Nafcillin (2)

A

Hepatoxicity

Agranulocytosis

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10
Q

Penicillin Coverage (3)

A

☑️Gram +
☑️No Gram - except N. meningitidis, Treponema, Lepto
☑️Anaerobic except Bacteroides fragilis

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11
Q

Aminopenicillin Coverage (3)

A

☑️Gram +
☑️Gram - (limited)
☑️Anaerobes except bacteroides fragilis

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12
Q

Anti-pseudomonal penicillins (2)

A

Carboxypenicillin

Ureidopenicillin

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13
Q

Carboxypenicillins are antipsuedomonal. What are the 2 drugs under this class

A

Carbenicillin
Ticarcillin

CAR nakasakay si pseudomonas

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14
Q

Ticarcillin is notorious for causing

A

Bleeding

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15
Q

Ureidopenicillins (PAM 4 Pseudomonas)

A

Piperacillin
Azlocillin
Mezlocillin

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16
Q

Penicillin Rash is what type of hypersensitivity

A

Type IV

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17
Q

All cabapenems are epileptogenic but the most epilectogenic is

A

Imipenem

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18
Q

Carbapenems (4)

A

Ertapenem
Meropenem
Doripenem
Imipenem

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19
Q

Carbapenem with great coverage for pseudomonas is

A

Doripenem

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20
Q

Carbapenem use for ESBL infection

A

Imipinem

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21
Q

Carbapenem Coverage (4)

A

☑️Gram +
☑️Gram -
☑️Anaerobes
☑️Pseudomonas EXCEPT ERTAPENEM

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22
Q

Monobactam Coverage

A

Gram -

Pseudomonas

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23
Q

Monobactam are only available in ? form

A

intravenous

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24
Q

Aztreonam Coverage (HENPECKSSS+)

A 
H. influenzae
Enterobacter
Neisseria
Proteus
E.coli
Klebsiella
Serratia
Salmonella 
Shigella
Pseudomonas
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25
Q

1st Gen CEPH except (3) DRO-ZO-LEX

A

CefDROxil
CefaZOlin
CefaLEXin

26
Q

2nd Gen CEF + vowel EXCEPT (3) PRO-META-LOR

A

CefPROzil
CefMETAzole
LORAcarbef

27
Q

3rd Gen CEF + consonant EXCEPT (4)

Pera, Tax, Fix, Mo

A

CefoPERAzone
CefoTAXime
CeFIXime
MOxalactam (MX3)

28
Q

4th Gen Ceph (2) EPI-PIROME

A

EPI-PIROME

CefEPIme
CefPIROME

29
Q

5th Gen Ceph (2) TARO TOBI (TARO tayo TOBI)

A

CefTAROline

CefTOBIprole

30
Q

1st Gen Cov (PEcK +)

A

Proteus
E.coli
Klebsiella
Gram +

31
Q

2nd Gen Cov (HENPEcK +a)

A

H.influenzae
Enterobacter
Neisseria

Proteus
E.coli
Klebsiella
+anaerobe

32
Q

3rd Gen Cov (HENPEcKSSS)

A

H.influenzae
Enterobacter
Neisseria

Proteus
E.coli
Klebsiella

Serratia
Salmonella
Shigella

33
Q

4th Gen Cov (HENPEcKSSS and ?)

A

Pseudomonas

34
Q

5th Gen Cov (HENPEcKSSS, Pseudomonas + ?)

A

MRSA

35
Q

DOC for Community Acquired MRSA

A

Clindamycin

  • parehas C
36
Q

DOC for Hospital Acquired MRSA

A

Vancomycin

37
Q

IM Pen G

A

Bezathine Penicillin
Compliance of px is issue
Glutues maximus

38
Q

RF w/o carditis

A

21 days for 5 years or until 21 years of age which ever is longer

39
Q

RF w/ carditis (no valv inv)

A

IM Pen G every 21-30days for 10 years until 21 years old whichever is longer

40
Q

RF w/ carditis w/ valv

A

IM Pen G every 21-30days for 10 years until 40 years old (lifetime)

41
Q

Pen V

A

Oral, vivig

42
Q

PCMC binds to what structure of the bacteria

A

PBP (not PBP2A - MRSA)

43
Q

Agranulocytosis

A

Nafcillin

Methimazole

44
Q

IsOXAzoyl Penicillin (OCD)

A

Maganda yung isoxazoyl ring sasabihin sa penicillinase, ako na lang iattack mo so si beta lactam ring unattack yarn
OXAcillin
ClOXAcillin
DiclOXAcillin

45
Q

Usage of CONDOM

A

Methicillin Sensitive Staph Aureus

46
Q

Aaaaaaaaminopenicillin

A

Broad-spectrum

47
Q

Ampicillin - Gentamicin interaction

A

Synergism (1+1+3)

48
Q

Most potent for pseudomonas infection

A

Piperacillin

PP

49
Q

Beta-lactamase inhibitor is NOT ANTIBIOTIC. What type of association

A

Potentiation (0+1=2)

50
Q

Beta lactam penicillin + Beta lactamase inhibitors coverage

A

Gram +
Gram -
Anaerobes incl. bacteroides fragilis

51
Q

Beta lactam antibiotics w/o cross sensitizing w/ Penicillin

A

Carbapenem

Monobactam

52
Q

DOC for penicillin allergic pxs?

A

Macrolide esp. Erythromycisn

53
Q

Erythematous rash: Hypersensitivity to Pen.

Maculopapular rash: ?

A

Penicillin Rash - Type IV

54
Q

6-APA: Penicillins

?: Cephalosporin

A

7-ACA

55
Q

The only generation of cephalosporin with anaerobe coverage?

A 
2nd generation
Cefamycin - TETA META FOX
cefotetan
cefmetazole
cefoxitin
56
Q

3rd Gen w/ pseudomonas coverage?

A

Taz na maraming Pera
CefTAZidime
CefPERAzone

57
Q

All beta lactam antibiotics PCMC are epileptogenic but the most epileptogenic is

A

Carbapenem

58
Q

Imipenem degrades your dehydropeptidase enzyme in the renal tubule. What drug is use to inhibit this enzyme?

A

Cilastatin

59
Q

Azteonam has the same coverage as your?

A

CeftaAZidime (HENPECKSSS+)

60
Q

Monobactam can be given to patients w/ ?

A

meningitis

61
Q

Monbactam ADR?

A

Transaminitis

62
Q

Pnematocoele

A

Staph aureus

Pharmacology (13 decks)

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