Antibiotics: Beta Lactam Antibiotics Flashcards by SHAILA BAUTISTA

Concentration Dependent (QuAA-Met-Dap-Poly)

Quinolones
Aminoglycosides
Azithromycin
Metronidazole
Daptomycin
Polymyxin

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The only macrolide that is concentration dependent

Azithromycin

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Beta-Lactam Inhibitors (PCMC)

Penicillin
Cephalosporin
Carbapenem
Monobactams

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Penicillin has coverage for anaerobic bacteria EXCEPT

Bacteroides Fragilis

- cant give to intraab infection

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Penicillins does not have gram negative coverage EXCEPT (3)

Neisseria meningitidis (NOT N. gonorrhoeae)
Treponema pallidum
Leptospira spp.

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Penicillinase-resistant Penicillins (CONDM)

Cloxacillin
Oxacillin
Naficillin
Dicloxacillin
Methicillin

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Methiciliin is off the market due to high incidence of

Interstitial Nephritis

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What gene is responsible for MRSA

Mec A gene

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ADR of Nafcillin (2)

Hepatoxicity

Agranulocytosis

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Penicillin Coverage (3)

☑️Gram +
☑️No Gram - except N. meningitidis, Treponema, Lepto
☑️Anaerobic except Bacteroides fragilis

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Aminopenicillin Coverage (3)

☑️Gram +
☑️Gram - (limited)
☑️Anaerobes except bacteroides fragilis

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Anti-pseudomonal penicillins (2)

Carboxypenicillin

Ureidopenicillin

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Carboxypenicillins are antipsuedomonal. What are the 2 drugs under this class

Carbenicillin
Ticarcillin

CAR nakasakay si pseudomonas

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Ticarcillin is notorious for causing

Bleeding

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Ureidopenicillins (PAM 4 Pseudomonas)

Piperacillin
Azlocillin
Mezlocillin

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Penicillin Rash is what type of hypersensitivity

Type IV

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All cabapenems are epileptogenic but the most epilectogenic is

Imipenem

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Carbapenems (4)

Ertapenem
Meropenem
Doripenem
Imipenem

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Carbapenem with great coverage for pseudomonas is

Doripenem

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Carbapenem use for ESBL infection

Imipinem

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Carbapenem Coverage (4)

☑️Gram +
☑️Gram -
☑️Anaerobes
☑️Pseudomonas EXCEPT ERTAPENEM

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Monobactam Coverage

Gram -

Pseudomonas

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Monobactam are only available in ? form

intravenous

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Aztreonam Coverage (HENPECKSSS+)

H. influenzae
Enterobacter
Neisseria
Proteus
E.coli
Klebsiella
Serratia
Salmonella 
Shigella
Pseudomonas

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1st Gen CEPH except (3) DRO-ZO-LEX

CefDROxil CefaZOlin CefaLEXin

2nd Gen CEF + vowel EXCEPT (3) PRO-META-LOR

CefPROzil CefMETAzole LORAcarbef

3rd Gen CEF + consonant EXCEPT (4) | Pera, Tax, Fix, Mo

CefoPERAzone CefoTAXime CeFIXime MOxalactam (MX3)

4th Gen Ceph (2) EPI-PIROME

EPI-PIROME CefEPIme CefPIROME

5th Gen Ceph (2) TARO TOBI (TARO tayo TOBI)

CefTAROline | CefTOBIprole

1st Gen Cov (PEcK +)

Proteus E.coli Klebsiella Gram +

2nd Gen Cov (HENPEcK +a)

H.influenzae Enterobacter Neisseria Proteus E.coli Klebsiella +anaerobe

3rd Gen Cov (HENPEcKSSS)

H.influenzae Enterobacter Neisseria Proteus E.coli Klebsiella Serratia Salmonella Shigella

4th Gen Cov (HENPEcKSSS and ?)

Pseudomonas

5th Gen Cov (HENPEcKSSS, Pseudomonas + ?)

MRSA

DOC for Community Acquired MRSA

Clindamycin - parehas C

DOC for Hospital Acquired MRSA

Vancomycin

IM Pen G

Bezathine Penicillin Compliance of px is issue Glutues maximus

RF w/o carditis

21 days for 5 years or until 21 years of age which ever is longer

RF w/ carditis (no valv inv)

IM Pen G every 21-30days for 10 years until 21 years old whichever is longer

RF w/ carditis w/ valv

IM Pen G every 21-30days for 10 years until 40 years old (lifetime)

Pen V

Oral, vivig

PCMC binds to what structure of the bacteria

PBP (not PBP2A - MRSA)

Agranulocytosis

Nafcillin | Methimazole

IsOXAzoyl Penicillin (OCD)

Maganda yung isoxazoyl ring sasabihin sa penicillinase, ako na lang iattack mo so si beta lactam ring unattack yarn OXAcillin ClOXAcillin DiclOXAcillin

Usage of CONDOM

Methicillin Sensitive Staph Aureus

Aaaaaaaaminopenicillin

Broad-spectrum

Ampicillin - Gentamicin interaction

Synergism (1+1+3)

Most potent for pseudomonas infection

Piperacillin PP

Beta-lactamase inhibitor is NOT ANTIBIOTIC. What type of association

Potentiation (0+1=2)

Beta lactam penicillin + Beta lactamase inhibitors coverage

Gram + Gram - Anaerobes incl. bacteroides fragilis

Beta lactam antibiotics w/o cross sensitizing w/ Penicillin

Carbapenem | Monobactam

DOC for penicillin allergic pxs?

Macrolide esp. Erythromycisn

Erythematous rash: Hypersensitivity to Pen. | Maculopapular rash: ?

Penicillin Rash - Type IV

6-APA: Penicillins | ?: Cephalosporin

7-ACA

The only generation of cephalosporin with anaerobe coverage?

``` 2nd generation Cefamycin - TETA META FOX cefotetan cefmetazole cefoxitin ```

3rd Gen w/ pseudomonas coverage?

Taz na maraming Pera CefTAZidime CefPERAzone

All beta lactam antibiotics PCMC are epileptogenic but the most epileptogenic is

Carbapenem

Imipenem degrades your dehydropeptidase enzyme in the renal tubule. What drug is use to inhibit this enzyme?

Cilastatin

Azteonam has the same coverage as your?

CeftaAZidime (HENPECKSSS+)

Monobactam can be given to patients w/ ?

meningitis

Monbactam ADR?

Transaminitis

Pnematocoele

Staph aureus