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Pharmacology > Anti-TB > Flashcards

Anti-TB Flashcards

1
Q

Category I Indication (3)

A

New PTB
New Miliary TB
New ETB (except CNS/ bones/ joints)

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2
Q

Category I Regimen

A

2HRZE
4HR

6 months total

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3
Q

Category Ia Indication (2)

A

CNS TB

TB bones/joints

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4
Q

Category Ia Regimen

A

2HRZE
10 HR

12 months total

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5
Q

Category II Indication (1)

A

Retreatment of Rif susceptible PTB & ETB (except CNS/bones/joints)

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6
Q

Category II Regimen

A

2HRZES
1HRZE
5HRE

8 months total; Mawawala muna si S tas si Z

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7
Q

Category IIa Regimen

A

2HRZES
1HRZE
9HRE

12 months total

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8
Q

Rifampicin (R) MOA

A

(-) RNA polymerase

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9
Q

Isoniazid (H) MOA

A

(-) enoyl reductase

(-) mycolic acid layer synthesis

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10
Q

Pyrazinamide (Z) MOA

A

Dec. pH -> disturb membrane transportation & permeability

(-) uptake of uracil, methionine, serine

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11
Q

Ethambutol (E) MOA

A

Arabo si Ethan na di pumapatay

(-) Arabinosyl-transferase
(-) Arabinogalactan layer

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12
Q

Streptomycin (S) MOA

A

(-) 30s

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13
Q

When giving this anti-TB drug, always give vitamin B complex (part. Vit. B6) to prevent peripheral neuropathy

A

Isoniazid

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14
Q

Isoniazid Mechanism of Resistance (MOR)

A

Mutation in KAtG gene

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15
Q

Rifampicin MOR

A

Mutation in rpoB gene (most common mutation in ant-tb)

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16
Q

Pyrazinamide MOR

A

Mutation in pncA gene

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17
Q

What do you call the ability of Anti-TB drugs to kill all remaining organism?

A

Sterilizing activity

18
Q

Which of the anti-TB has sterilizing activity? (2)

A

steRiliZing

Rifampicin
Pyrazinamide

19
Q

Which of the anti-TB targets intracellular bacilli only?

A

Pyrazinamide

20
Q

Pyrazinamide ADR

A

Hyperuricemia

21
Q

Ethambutol ADRs (2)

A

Optic Neuropathy
RED-GREEN color blindness (Christmas colors)

BLUE-GREEN? = Sildenafil (Viagra)

22
Q

Reasons to use 2nd line Anti-TB drugs? (3)

A
  1. 1st line are not available
  2. Severe ADR
  3. Resistance
23
Q

The last resort in the tx of TB MDR; Tx for Hansen’s Dse

A

Clofazimine

24
Q

Bedaquilline MOA

A

(-) mycobacterial ATP synthase/ complex 5 of ETC

25
Q

Delamanid MOA

A

(-) mycolic acid biosynthesis

26
Q

Acid Fast (CAM)

A

C -Carbol Fuhsin
A- Acid Alcohol VS (Acetone Alcohol in GS)
M- Malachite green

27
Q

Complex Lipid present in peptidoglycan of TB is composed of (4)

A

Arabinoglycan layer
Mycolic Acid
Cord Factor
Wax D

28
Q

Mendel-Mantoux test is what type of hypersensitivy?

A

Type IV Delayed Type

Only type that that is T-cell mediated

29
Q

TST > 10mm is normal

Who are >5mm, positive na?

A 
4C
immunoCompromised
Close Contact
Clinical S/Sx
Chest Xray
30
Q

Px with both PTB and ETB, what is the classification?

A

PTB pa rin mga olol

31
Q

Px has hx of TB and now is taking TB drugsfor 3 weeks. Classification?

A

New case.
Cut off: 1 month
> 1 month = Retreatment

32
Q

Why do we have 4 drugs in the initiation phase of TB tx?

A

To dec. resistance

33
Q

Retreatment involves ?

A

Streptomycin

34
Q

Streptomycin is administered?

A

Intramuscularly (IM)

35
Q

Pyrazinamide is a prodrug it is activated inside the cell and becomes?

A

Pyrazinoic acid

36
Q

All anti-TB drugs are bacteriocidal except

A

Ethambutol

37
Q

Which of the anti-TB targets extracellular bacilli only?

A

Streptomycin

38
Q

All anti-TB drugs are hepatotoxic but the most hepatotoxic are? (2)

A

Pyrazinamide

Isoniazid

39
Q

What anti-TB drug can cause drug-induced lupus?

A

Isoniazid

40
Q

The most common ADR of Isoniazid is?

A

Peripheral Neuropathy

Vit B6

41
Q

What anti-TB drug can cause red-orange secretions?

A

Rifampicin

Luha, ihi orange

42
Q

Which of the ff. novel anti-TB drugs has the same MOA w/ Isoniazid?

A

Delamanid

Pharmacology (13 decks)

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