GI - 8 Antibiotic Associated Diarrhea and C. Diff

Question 1

Is antibiotic-associated diarrhea common?

Answer 1

Hells yes

Question 2

What resolves antibiotic associated diarrhea?

Answer 2

Discontinuation of antibiotic

Question 3

What’s the most common cause of antibiotic-associated diarrhea?

Answer 3

changes in colonic bacterial fermentation of carbohydrates (C diff causes fewer cases)

Question 4

What’s the cause of Antibiotic-associated colitis?

Answer 4

C diff

Question 5

How does Antibiotic-associated colitis happen?

Answer 5

Antibiotics knock out good flora as well as bad flora. Then a hospital patient/staff passes C. Diff to them and they get this.

Question 6

Drug to treat antibiotic associated colitis

Answer 6

Clindamycin

Question 7

2 examples of fluoroquinolones:

Answer 7

Ciprofloxicin, levofloxicin

Question 8

Mild-mod greenish, foul smelling watery diarrhea
Lower abdominal cramps when going to the bathroom
Normal or mild left lower quadrant tenderness

Answer 8

C diff diarrhea

Question 9

The key 2 symptoms of C Diff colitis are:

Answer 9

Watery diarrhea

with mucous and lots of blood

Question 10

What’s a test to diagnose C diff? How does it work?

Answer 10

PCR - tests for toxin B (one of A&B toxins made by C diff)

Question 11

Yellow adherent plaques over colonic mucosa is a sign of:

Answer 11

Pseudomembranous colitis

Question 12

What imaging test is done for patients with severe symptomatology when rapid diagnosis needed?

Answer 12

Sigmoidoscopy

Question 13

Drug for treating Pseudomembranous colitis

Answer 13

Metronidazole

Question 14

What’s the difference between Antibiotic-associated colitis and antibiotic associated pseudomembranous colitis?

Answer 14

Pseudomembranous colitis is a very severse case of antibiotic-associated colitis. It has yellow adherent plaques as well

Question 15

Drug for relapses of antibiotc pseudomembranous colitis

Answer 15

**Most relapses respond promptly to a 2nd course of metronidazole therapy.