GI - 5 Liver Disease pt 2 Flashcards
Sensitive and precise marker of viral replication and infectivity
Small amounts can persist long after recovery.
Tells how much of the virus is in their blood
HBV DNA
Hep _ only exists with Hep _
Hep D only exists with Hep B
Progression from acute to chronic hepatitis B is primarily determined by:
the age at infection. Having Hep B since a child – highest chance of going on to have Chronic Hep B
The persistence of which HBV antigen in the blood indicates carrier state?
HBsAg
What does carrier state mean?
chronic disease
in terms of hep B and D,
What does coinfect mean?
what does superinfect mean?
Which is worse?
Coinfect: D & B come together
Superinfect: already have B and then D - worse
Treating Hep C depends on ___
the genotype
Most are anicteric and asymptomatic with mild course
Jaundice:
Hep C
How do you check if someone cleared Hep C?
check for Antibody for Hep C Virus: if they have it it means they should be tested for the viral load. If they don’t have viral load, then they cleared it.
Having Anti HCV in blood ___ mean recovery
Having Anti HCV in blood: DOES NOT MEAN RECOVERY ****
What is the treatment for Hep C/ Chronic Hep C? (2)
Interferon alpha
Peginterferon
Treatment for Hep C is reserved for:
Often treatment is reserved for patients whose serum HCV RNA levels fail to clear after 3-4 mos
If a patient is AntiHCV+ you can assume they are no longer infections
True
False
False. You have to do the viral load
What Hep is this?
Self limited illness and NO CARRIER STATE*
High mortality rate in pregnant women(10-20%)*
Not in the USA
Hep E
What 2 types of Hep have no carrier state?
Hep A and E have no carrier state (if you carry it you will show symptoms)
Describe the 4 general phases of Hepatitis
- Prodromal phase: Malaise, myalgias, arthralgias, fatigability , URI symptoms, anorexia
Nausea, vomiting, diarrhea, or constipation (vague)
+/- Serum sickness in acute HBV
Fever is low grade if any (except HAV)
RUQ or epigastric abdominal pain - Icteric phase: Jaundice occurs after 5-10 days if at all
May occur with prodromal symptoms - Convalescent phase – getting better
- Course & Complications: Hepatitis B, D, C, G may become chronic**
A&E do not become chronic
What general phase of Hepatitis is this?
Prodromal phase: Malaise, myalgias, arthralgias, fatigability , URI symptoms, anorexia
Nausea, vomiting, diarrhea, or constipation (vague)
+/- Serum sickness in acute HBV
Fever is low grade if any (except HAV)
RUQ or epigastric abdominal pain
- Prodromal phase
What general phase of Hepatitis is it when Jaundice may occur?
- Icteric phase
Which general phase of Hepatitis involves getting better, getting an appeitite back and such?
- Convalescent phase
What types of Hepatitis may become chronic? Which do not?
Hepatitis B, D, C, G may become chronic**
A&E do not become chronic
4 signs of hepatitis
Hepatomegaly
Liver tenderness
Splenomegaly
Lymphadenopathy - Cervical and epitrochlear
___ often precedes jaundice
Bilirubinuria
A general lab finding for Hep is
High ALT/AST
How do you prevent getting Hep A from someone who has it?
Immune globulin should be given to all close contacts and persons who consume food prepared by infected individual
