GI - 6 Diarrhea pt 3 Flashcards
What is Whipple’s disease?
a bacterial disease that can cause malabsorption
2 imaging tests that are Sensitive for the diagnosis of chronic pancreatitis and pancreatic cancer
Abdominal CT and endoscopic ultrasonography
What is Useful in patients with bile salt-induced diarrhea secondary to intestinal resection or ileal disease?
Cholestyramine
Fats are broken down by ____ to monoglycerides and fatty acids that form micelles with bile salts
pancreatic lipase
Proteins are hydrolyzed by ___ to di- and tripeptides and amino acids
pancreatic proteases
Name 4 fat soluble vitamins. What can happen?
A,D,E,K. If malabsorbed, causes bleeding, osteoporosis, and hypocalcemia
Insufficient intraluminal concentrations of pancreatic enzymes or bile salts
Impaired intraluminal digestion
What is Impaired intraluminal digestion?
Insufficient intraluminal concentrations of pancreatic enzymes or bile salts
large, greasy, foul-smelling stools are signs of what diarrhea disease?
Steatorrhea
Wt loss, gaseous distention and flatulence, Steatorrhea are symptoms of
Pancreatic insufficiency (causing impaired digestion)
Malabsorption of specific nutrients may occur as a result of deficiency in an isolated brush border enzyme. What Phase? What enzyme deficiency is caused by this?
Mucosal phase. Lactase deficiency
What phase? Obstruction of the lymphatic system results in impaired absorption of chylomicrons and lipoproteins
Steatorrhea and significant enteric protein losses or “protein-losing enteropathy”
Absorptive phase
Permanent dietary disorder caused by an immunologic response to __
gluten
Celiac disease is 100X more present in whom?
Whites of North Europe ancestry
“Classic” symptoms of malabsorption (of celiac disease) includes:
including diarrhea, steatorrhea, weight loss, abdominal distention, weakness, muscle wasting, or growth retardation
Physical examination
May be normal in mild cases
May reveal signs of malabsorption
Celiac disease
Cutaneous variant of celiac disease
Characteristic skin rash consisting of pruritic papulovesicles over the extensor surfaces of the extremities and over the trunk, scalp, and neck
Dermatitis herpetiformis
Limited proximal involvement anemia involves what problems?
Iron deficiency
More extensive anemia involves
Vit B deficiency
prothrombin time tests for:
Fat soluble vitamin absorption
Which patients get tests for celiac disease?
Anyone whom there is a suspicion of celiac disease
