GI - 5 Liver Disease pt 1 Flashcards
Which types of Hepatitis are DNA? RNA?
All Hep’s besides B are RNA viruses. B is a DNA virus
Fecal-oral
Increased by crowding and poor sanitation
Contaminated water/food including undercooked shell fish
Excreted in feces for 2 weeks before clinical illness
No chronic carrier state
Hep A
It’s acute and goes away. Not chronic.
Hep A
Spiking fever is a key sign of
Hep A
Dark urine and light stools.
Fatigue, malaise, nausea, vomiting, anorexia
Right upper quadrant pain
Jaundice and hepatomegaly.
Hep A
ALT > AST (both are elevated) is a sign of
Hep A, B
What are ALT & AST on a lab?
– liver enzymes (amino transferases); will have high levels during liver disease
What is GTT on a lab?
lab that determines if high alk phos is from liver or the bone
Acute or chronic? Hep A
Acute and goes away in 3 months. Hepatitis A: DOES NOT CAUSE CHRONIC LIVER DISEASE!
How can antibody levels identify Hep A?
Excreting in feces is how it’s spread. IgM raises first, then IgG raises second.
What’s the only DNA Hep virus?
Hep B
1 way Hep B is transmitted is
Heterosexual sex
Aninteric means:
Icteric means:
Aninteric - no jaundice
Icteric - jaundice
What is the best indicator of Hep B? Why?
Prothrombin time - coagulation proteins are made in the liver. It shows how quickly you can clot.
What are LFT’s?
Liver function test. Tests if the liver is working normally or not.
The first thing that will appear in the blood when you are sick with Hep B, will persist throughout sickness
Hep B Surface Antigen
What is Hep B Surface Antigen?
The first thing that will appear in the blood when you are sick with Hep B, will persist throughout sickness.
Having Hep B Surface Antigen for > 4 means:
Chronic Hep B
Chronic Hep B is defined as:
having Hep B Surface Antigen in blood for > 4 months
What is Anti Hep B surface antigen?
the antigen to HBsAg. Only appears when you have cleared the disease. You don’t have HBsAg anymore. Only Anti HBs.
If you’re vaccinated you will have __ in the blood. You won’t have ___ in blood.
you will have Anti HBs
you won’t have HBsAg
Why should you test for Hep B core antibody when testing for Hep B?
It fills the window period between HBsAg and Anti HBs.
Having what in blood means you were vaccinated for Hep B?
IgG
What is found in the blood in only only in very infectious/unlucky cases of Hep B? Indicates viral replication and infectivity
HBeAg - Hep B ‘E’ Antigen
