GI Flashcards
what organs make up the GI tract?
mouth
most of the pharynx
esophagus
stomach
small intestines
large intestines
what are the six accessory glands?
teeth
tongue
salivary glands
liver
gall bladder
pancreas
what is the flap of cartilage which allows food to enter the larynx?
epiglottis
what are the six steps of the digestive system?
ingestion
secretion
mixing and propulsion
digestion
absorption
defecation
what is the difference between digestion and hydrolysis?
digestion = physical breakdown of food
hydrolysis = chemical break down of food
what are the four layers of the GI tract?
muscosa
submuscosa
muscularis
serosa
what layer of the GI contains your malt?
muscosa lamina propria layer
what system regulates the GI tract?
enteric nervous system
what nerve helps regulate the GI tract?
vagus nerve X
what nervous system activates rest and digest?
parasympathetic
what is the large serous membrane of the body?
peritoneum
what does the parietal peritoneum cover?
abdominopelvic Cavity
What does the retroperitoneal cavity cover?
any organ that lies on the posterior abdominal wall
(kidney, colons of the large intestine, duodenum of the small intestine, pancreas)
describe each of the following :
greater momentum
falciform ligament
lesser momentum
mesentery
mesocolon
greater momentum (fatty drape over the small intestine)
falciform ligament (attaches the liver to the anterior abnormal and diaphragm)
lesser momentum (suspends the stomach and duodenum from the liver)
mesentery (binds the jejunum and ileum together)
mesocolon (binds the transverse colon and sigmoid colon of the large intestine to the posterior wall)
where is the parotid gland located?
inferior and anterior to the ears
between the mass ester and its skin overlying
what purpose does saliva have?
cleansing
increase secretion to help with breakdown of food
where is the submandibular gland located?
floor of the mouth, medial and partial inferior to the body of the mandible
where is the sublingual gland located?
beneath the tongue and superior to the submandibular glands
how much saliva is water? solute?
water 99.5%
solute 0.5%
how many teeth are permanent? deciduous?
permanent 32
deciduous 20
what muscle forms the floor of the oral cavity?
tongue
what enzymes contribute to chemical digestion?
salivary amylase and lingual lipase
what do salivary amylase enzymes do?
break down starches which break down into monosaccharides which are absorbed into the bloodstream
where can you find salivary amylase enzymes?
oral cavity to the stomach where stomach acid then takes over
what does lingual lipase do?
active in acidic environments and breaks down triglycerides into fatty acids and diglycerides
what is the pharynx?
extends from the internal nares to the esophagus portioner to and anterior to the larynx
what three divisions do the pharynx make up?
nasopharynx
oropharynx
laryngopharynx
what is the function of each division of the pharynx?
nasopharynx (respiration)
oropharynx (respiration and digestion)
laryngopharynx (respiration and digestion)
what is the collapsible muscular tube which lies posterior to the trachea?
esophagus
what is the hiatal hernia?
part of the stomach which protrudes above the diaphragm
what four layers make up the esophagus?
mucosa
submucosa
muscualris
adventitia
does the esophagus have digestive enzymes or absorption properties?
no
based on the muscular layer of the esophagus, what parts are made of skeletal muscles or smooth muscles?
superior 1/3 (skeletal)
middle 1/3 (skeletal and smooth)
inferior 1/3 (smooth)
what are the three phases of deglutition?
voluntary stage
pharyngeal stage
esophageal stage
what does the stomach connect?
the esophagus to the duodenum
what is gastroenterology?
a medical speciality that deals with the structure soft the stomach and intestine
what are the four parts f the stomach?
cardia
funds
body
pyloric
what are the three regions of the pyloric ?
pyloric antrum (connects the body to the stomach)
pyloric canal
pylorus (connects to duodenum)
what are rugae?
wrinkles in the stomach
what is another word for sphincter?
valve
what is the concave, medial border of the stomach called?
convex lateral border?
concave = lesser curvature
convex = greater curvature
what cells secrete mucus?
surface mucous and mucous neck cells
what do partial cells produce?
intrinsic factor (B12) and hydrochloric acid
what do chief cells secrete?
pepsinogen and gastric lipase
what are G cells?
found in the pyloric antrum and secrete gastrin into the blood stream
is the oblique layer limited to the body of the stomach?
yes
what is propulsion?
waves of movement causes gastric contents to move from the body of the stomach to the antrum
what is retropulsion?
when contents of the stomach are forced back into the body of the stomach
what is the soupy lipid of contents found in the stomach referred to?
chyme
When do proteins become digested?
in then stomach
what digest protein in the stomach?
pepsin
when is pepsin most effective?
acidic environment
what things only get absorbed in the stomach and no were else in the body?
aspirin and alcohol
where do most digestion and absorption take place?
small intestine
what three structures are found in the small intestine?
circular folds
villi
microvilli
what are the three divisions of the small intestine from top to bottom?
duodenum
jejunum
ileum
what valve divides the ileum from the large intestine?
ileocecal sphincter
what cells are present in the small intestine and are able to produce mucus?
goblet cells
what do paneth cells do?
secrete lysozyme
what are payers patches?
groups of lymphatic nodules present on the ileum
what are burners glands?
secrete an alkaline mucus that helps neutralize gustier acid in the chyme
what do circular folds do?
large folds which are found in the small intestine. they cause chyme to spiral rather than travel in a straight line to help with absorption level increase
what are villi?
finger-like projections
increase the surface area of the epithelium
what are microvilli?
projections small than villi which create a brush border which appears fuzzy
what is segmentation?
mixing contractions that occur in portions of the intestine distended by large volumes of chyme
they do not push
what is migrating motility complex?
at the end of the small intestine
push chyme forward to prevent drying out
what breaks down / digest carbohydrates?
pancreatic amylase
what is emulsification?
breaking down of large lipid globules into small forms
is bile hydrophobic or hydrophilic?
both
where is bile secreted from?
liver
what is absorption?
passage of digested nutrients from the gastrointestinal tracts to blood or lymph
what are chylomicrons?
large spherical masses about 80mm in diameter
what are “fat soluble” vitamins?
A D E K
how do these vitamins (fat-soluble) become absorbed?
simple diffusion
what are “water soluble” vitamins?
B C
how does B12 become absorbed?
active transport
how much water is found in faces a day?
0.1 L
what is the terminal portion of the GI tract?
large intestine
what are the four main regions of the large intestine?
cecum
colon
rectum
anal canal
what is the appendix?
a twisted, coiled tube attached the the cecum of the large intestine
what are the four areas of the colon in order?
ascending
transverse
descending
sigmoid
is the internal anal sphincter smooth or skeletal muscle based? external anal sphincter?
internal (smooth)
external (skeletal)
where would most bacteria removal take place?
large Intestine
what is the difference between diarrhea and constipation?
diarrhea (increased volume of water and movement)
constipation (decreased volume of water and movement)
why is fibre important?
reduces risk of obesity, diabetes, atherosclerosis, gallstones, and colon cancer
what is the cephalic phase?
activated by smell, taste, sight, or thought of food
what is the gastric phase?
hormone release to pre for food intake
what is the intestinal phase?
once food enters the small intestine
what two ducts are found in the pancreas?
accessory duct
pancreatic duct
describe the duct system of the pancreas
pancreatic duct is the largest
joins common bile duct from the liver and gallbladder to enter the duodenum
become the hepatopancreatic ampulla
what are acini?
found in the pancreas and for 99% of clusters cells
what are islets of langerhans?
the 1% of pancreas cells
what is the heaviest gland?
liver
what makes bile? stores bile?
produced via liver
stored via gallbladder
what ligament divides the right and left gallbladder?
falciform ligament
what is the hepatic portal circulation?
carries blood from the GI organs and spleen to the liver
what does the hepatic portal vein do?
carries blood to the liver
what makes the hepatic portal vein?
superior mesenteric vein
splenic vein
what makes up the portal triad?
hepatic artery
hepatic vein
bile duct
what are the functions s of the liver?
carb metabolism
lipid metabolism
protein metabolism
processing drugs and hormones
excretion of bilirubin
synthesis bile salt
storage
phagocytosis
vitamin activation
what is anorexia?
represent loss of appetite
what is anorexia nervosa?
an eating disorder characterized by low weight, fear of gaining weight, and a string desire to be thin, resulting in food restriction
what is nausea?
ill-defined and unpleasant subjective sensation
normally results in vomitting
why is nausea normally preceded by?
anorexia
what is retching?
rhythmic spasmodic movements of the diaphragm, Chets wall, and abdominal muscles
what is another name for emesis?
vomitting
what is vomitus?
contents resulted from vomitting
what two centres are involved with vomtting?
vomiting centre
chemoreceptor trigger zone
distention or irritation of the GI tract also causes vomiting through the stimulation of the _______ _______ ________.
visceral afferent neurons
what hormones are found in the GI tract and in the vomiting centre or trigger zone?
dopamine
serotonin
opioid receptors
what hormones help stabilize after motion sickness?
norepinephrine
acetylcholine receptors
what is dysphagia?
difficulty in swallowing
what is painful swallowing called?
odynophagia
dynophagia
what is achalasia?
lower esophageal sphincter fails to relax because of a disruption in the input from ENS or the vagus nerve X
what is pyrosis?
heartburn
what can cause heartburn?
high fat diets increase chances
or gastric distention
what is gastroesophageal reflex disease (GERD)?
symptoms or mucosal damage produces by the abnormal reflux of content beyond or into the esophagus and to the oral cavity and lungs
what is two common manifestations of GERD?
heart burn
regurgitation (contents in the mouth or hypoarnyx)
what are strictures?
combination of scar tissue and edema which narrows the esophagus
what is gastritis?
inflammation of the gastric mucosa
what is uraemia?
high uric in the blood
what’s the difference between aspirin, alcohol, and infection acute gastritis?
aspirin = unaware
alcohol = vomiting, distress of gastric transient, bleeding and hematemesis
infection = violent symptoms
what is the most common cause of chronic gastritis?
helicobacter pylori
produces enzymes that interfere with gastric acidity
what is peptic ulcer disease?
a group of ulcerative disorders that occur in areas of the upper GI tract
what are common forms of peptic ulcers?
duodenal (more common) and gastric ulcers
what are the two medications that are common causes of bacteria H pylori?
aspirin
NSAIDS
what are the manifestations of peptic ulcers?
burning or cramp-like pain when stomach is “empty”
pain relieves by food or antacids
pain over a small area near midline of xiphoid
what is the most common complication of peptic ulcers?
hemorrhage
perforation
penatration
gastric obstruction
what are stress ulcers?
GI ulcerations that develop in relation to major stress
what are Cushing uclers?
another form of stress ulcers
what is a functional GI disorder characterized by variable combination of chronic and recurrent intestinal symptoms not explained by any abnormality ?
irritable bowel syndrome
what are the characterizers of IBS?
persistent or recurrent symptoms (pain, altered bowel function, bloating, nausea, anorexia)
the hallmark of IBS is abdominal pain which is relieved by defecation
change in consistency or frequency of stool
what is the difference between crohn and ulcerative colitis?
crohns ( ucerataion in the lower ileum to upper colon)
colitis ( ulceration in the distal large intestine)
what is worse crohn or colitis?
colitis
what is the hallmark for colitis?
false urges
what is the name of an out pouching in the body?
diverticulitis
where are you most likely to develop a diverticulum?
sigmoid or descending colon
how do you test for appendicitis?
perform rebound test
(between the ASIS and the umbilicals, place a fingertip pressure. pain should be present on compression and spastic on release)
what is the difference between non-inflammatory and inflammatory diarrhea?
non-inflammatory (large volume) non bleeding
inflammatory (small volume) bleeding
what can cause non inflammatory diarrhea?
E. coli. bacteria
how long is acute v.s. chronic diarrhea?
acute 4 days
chronic 4 weeks
what is volvulus?
twisting of the large intestine
what is the most common genetic disorder?
celiac disease
how much bile is produced daily?
600 - 1200 mL
what is cholestasis?
decrease bile flow due to impaired secretion of hepatocytes or obstruction of bile ducts
what is xanthomas?
fatty growths under the skin
what is pruritus?
itching skin
what happens when the body gets high levels of bilirubin in the blood?
skin turns yellow and develops jaundice
what gives you bile colour?
bilirubin
how does Jaundice occur?
excessive RBC destruction
obstruction of bile flow
impaired uptake/failure of the liver
decreased con junction go bilirubin
what is hemolysis?
loss of red blood cells
when does hemolytic jaundice occur?
excessive loss of RBC
when is it common to develop jaundice?
at birth (hyperbilirubinemia)
what two reactions do people have to hepatotoxic disorders?
phase 1 = chemical modifications
phase 2 = conversion of lipid-soluble substances
which form of hepatitis is spread via fecal-oral route?
A
E
what form of hepatitis is speards via blood or body fluids?
B
C
which hepatitis is the most common to develop from needle sharing?
D
can you spread hepatitis B without showing symptoms?
yes
describe hepatitis D
delta virus
must have hepatitis B virus to develop
what is superinfection hepatitis?
having B and D together
what is the difference between LDL and HDL?
LDL (bad cholesterol)
HDL (good cholesterol)
what is the role of HDL?
transports excess cholesterol to the liver
what is cholecystjts?
inflammation of the gallbladder
what are the phases of liver disease?
inflammation
fibrosis
cirrhosis
failure
what organ is common effected by excessive alcohol intake?
liver
what are the three kinds of alcohol-induced liver disease?
fatty liver
alcoholic hepatitis
alcoholic cerrhosis
what is ascites?
accumulation of fluid In the abdominal cavity
what is the most severe liver disease?
hepatic failure
what is factor hepaticas?
musty, sweetish oder of the breath in patients with liver failure
what is cholelithiasis?
gallstones
what is cholecystitis?
inflammation of the gallbladder
what is choledocholihiasis?
stones in the common bile duct
what is cholangitis?
inflammation of the common bile duct
what is the most common cause of chronic pancreatitis?
long term alcohol abuse
what is metabolism?
chemical reactions that occur in the body
what is the difference between catabolism and anabolism?
catabolism (chemical reactions that break down molecules)
anabolism (chemical reactions that combine simple molecules)
what is the name for ATP?
adenosine triphosphate
what make-up ATP?
ADP + P + energy
what two ways is ATP released via metabolism?
used to break down or build compounds
released via heat
what is oxidation reactions?
remove of electrons from an atom or molecule
what things transfer coenzymes?
NAD
FAD
what is reduction?
addition of electrons to a molecule
what is phosphorylation?
additional adding of a phosphate group to help create ATP
what are the functions of carbohydrates?
carbohydrates act as biofuel
functions as primary source of energy
functions in storage
framework for the body
What does glucose do for the body?
ATP production
amino acid synthesis
glycogen synthesis
triglyceride synthesis
what is the order of cellular respiration?
glycolysis
acetyl coenzyme A
kerb cycle
electron transport chain
where does the kerb cycle take place?
mitochondria
what is the difference between aerobic and anaerobic reactions?
aerobic requires oxygen
anaerobic requires no oxygen
what is chemiosmosis?
acts as a proton pump to expel H+ for mitochondrial matrix
what are the eight reactions of the kerb cycle?
entry of acetyl group
isomerization
oxidative decarboxylation
oxidative decarboxylation
substrate level of phosphorylation
dehydration
hydration
dehydrogenation
what does glucose anabolism create?
glycogen (stored in the liver)
what stimulates hepatocytes and skeletal muscles to carry out glycogen storage?
insulin
how much can your body store of glycogen?
500g (75 % in muscles and the rest in the liver)
what is the difference between glycogenolysis and glycogenesis?
glycogenolysis (spitting glycogen)
glycogenesis (creating glycogen)
what stimulates synthesizing of glucose?
cortisol
glucagon
thyroid hormone
what are lipoproteins?
allows lipids to become water soluble
what are apoproteins?
proteins in the outer shell that allows lipoproteins to occur
what are the four types of lipoproteins?
chylomicrons (small intestine)
VLDL (convert into LDL)
LDL (delivers to body cells for repair and synthesis steroids or proteins)
HDL (remove excess cholesterol of the body and blood)
what is lipolysis?
breaking down into fatty acids and glycerols
what inhibits lipolysis?
insulin
what do beta oxidation do?
metabolic pathway
breaks down fatty acids into acetyl CoA enzyme
in mitochrondra
where does protein catabolism take place?
adrenal cortex
what is deamination?
removal of amino acid groups to produce ammonia
what is the difference between kwashiorkor and marasmus?
kwashiorkor (deficiency of protein)
marasmus (progressive loss of muscle mass and fat stores because of inadequate food intake of proteins and clarions)
what is the entry into the kerb cycle?
acetyl coenyzme A
when does respiration occur?
when there is enough oxygen
what is the abortive state?
ingested nutrients enter the blood stream
what is the post-absorptive state?
absorption of nutrients in GI tract is complete
how long does a meal need to be completely reabsorbed?
4 hours
what is the bodies main source of energy?
glucose
where are most dietary lipids stored?
adipose tissue
what is lipogensis?
converting glucose and amino acids to fatty acids for synthesis of triglycerides
where does glycogenesis take place?
hepatocytes and muscle fibres
where does lipogenesis take place?
adipose cells and hepatocytes
what is the main challenge of the post absorptive state?
maintain blood glucose levels
what is glucose sparing?
when the body switches its main source of energy from glucose
what reactions occur due to glucose sparing?
catabolism of fatty acids
catabolism of lactic acid
catabolism of amino acids
catabolism of ketone bodies
what is the difference between fasting and starvation?
fasting (going without food for many hours to a few days)
starvation (going weeks or months without little or inadequate food intake)
what is a dramatic metabolic change that occurs in starvation?
ketone bodies become the main source of energy
what is the overall rate at which metabolic reactions use energy?
metabolic rate
what is the body’s quiet, resting, and fasting condition?
basal state
What is the measurement obtained under these conditions if fasting and starvation?
basal metabolic rate
what things effect metabolic rate?
hormones
exercise
nervous systen
body temperature
ingestion
age
other
what region of the World would greatly affect metabolic rates?
increase in norther areas of the world
what are the four heat transfers?
conduction (heat exchange between molecules of two materials)
convection ( movement of fluids between areas)
radiation ( transfer in the form of rays without physical touch)
evaporation (liquid to air)
what form of heat transfer do humans lose most their heat to?
radiation and evaporation (movements)
what area of the Brian controls body temperature?
preoptic area or thalamus
how does the thermoregulatory work?
vasoconstriction to keep heat inside the body
release of epinephrine and norepinephrine (increases heat production)
shivering to increase muscles tone and heat production
thyroid hormones rise temp.
what degree does it have to be to experience hypothermia?
35C or below internal body temp
what is a calorie?
amount of energy in the form of heat required to raise temp. 1 gram of water 1 degree
what things contribute to total metabolic rate?
basal metabolic rate
physical activities
NEAT
food-induced temperature
what is the difference between leptin and adiposity?
leptin (product of obesity)
adiposity (total body fat)
what is involved I’m the regulation of food intake and increases appetite?
ghrelin
what does the following do for satiety?
neuropeptide Y
melanocrotin
neuropeptide Y (stimulates food intake)
melanocortin (inhibits food intake)
what are the main types of nutrients?
water
carbohydrates
lipids
proteins
minerals
vitamins
how many extra calories does a women need an extra amount during pregnancy?
when breastfeeding?
300
500
what are inorganic elements?
minerals
what does the following do for the body?
calcium
chloride
cobalt
copper
fluoride
iodine
calcium (bone formation and maintenance)
chloride (pH stomach regulation)
cobalt (RBC maintenance)
copper (catalyst for hemoglobin)
fluoride (strengthen teeth and bones)
iodine (thyroid hormone synthesis)
what does the following do for the body?
iron
magnesium
phosphate
potassium
sodium
zinc
iron (kills bacteria)
magnesium (catalyst for intracellular nerve impulses)
phosphate (bone formation and maintenance)
potassium (osmolarity mainatenacene)
sodium (osmotic pressure)
zinc (enzymes)
what are organic compounds that acts as a catalyst for chemical reactions?
vitamins
do vitamins create angry?
not directly
what are provitamins?
raw materials
what vitamin is produced in the GI?
K
what does vitamin A do?
provides night vision
what are antioxidants vitamins?
C E and beta carotene
what are dextrins?
short-chain fatty acids absorbed by the GI tracks
what does fibre help with?
reduces the risk of colon cancer
general health benefits
reduces cardiovascular disease
controls weight
controls constipation and diarrhoea
prevents hemorrhoids
what are some soluble fibres?
fruits, oats, barley, legumes
what are some insoluble fibres?
vegetables, wheats, grains
what is genetically modified food?
food modified by genetic manipulation
what is MSG?
a flavour enhancer
what are excitoxins?
a form of glutamic acid that has high levels in animal studies causing damge to areas of the brain and the BBB
what does refined food cause?
increased blood sugar and can lead to fasr growing cancer as well as increase chances of diabtets
what are phytochemicals?
produced by plants
descibre the following:
allyl sulfides
dithiolthione and isothiocynates
indoles
isoflavones
lignans
flavonoids
carotenoids
allyl sulfides (help eliminate toxin compounds)
dithiolthione and isothiocynates (helps detoxify carcinogens)
indoles (interferes with estrogen metabolism)
isoflavones (affects cancer risk)
lignans (anti-estrogen)
flavonoids (antioxidants and hormal properties)
carotenoids (gives plants thier pigment)
what vitamins should men and womne over 60 take?
vitamin D
what two things should all pregnant women take?
folic acid and iron
what is the difference between priamry and secondary starvation?
priamry = inadequate food intake
secondary = diseas conditions that cause tissue wasting
what is the difference between android and gynoid obesity?
android (apple shaped, more common in men)
gynoid (oear shaped, more common in women)
what is pica?
craving non nutritive foods such as paint or feces