Gestational Trophoblastic Disease Flashcards
1
Q
risk fx of molar preg
A
- prior hx
- maternal <25 or >40
- prior spontaneous abortion
- diff conceiving
- beta caroten/vitamin A deficiency?
- asian
2
Q
molar trophoblastic neoplasia
A
- always gestational
- villi
- paternal DNA OVERABUNDANCE –> preferentially makes extra embryonic tissues
3
Q
non-molar trophoblastic neoplasia
A
- no villi
- non-gestational choriocarcinoma
- ovary/testes/chest
4
Q
complete mole
A
- single (or 2) sperm + empty egg
- sperm REDUPLICATES (end-duplication) forming “complete” 46 chromosome set
- 46 XX, or 46 XY
- higher CA risk
- uniparental (androgenetic)
5
Q
partial molar pregnancy
A
- egg Fert by 2 sperm
- one sperm reduplicates itself (69 XXY, 92 XXXY)
- biparental
6
Q
paternal DNA preferentially makes
A
extra-embryonic tissues
7
Q
maternal DNA preferentially makes
A
embryonic tissues
8
Q
NLRP7
A
inactivates maternal genes
9
Q
p57
A
- kinase inhibitor
- apoptosis
- normally express in maternal tissue and villi when maternal DNA present
- molar preg –> NOT expressed
10
Q
partial hydatiform mole
A
xs placental tissue, xs paternal DNA
-IUGR, syndactyly
11
Q
vesicular villi grossly ID, often >1cm
A
complete hydatidiform mole
12
Q
which mole has higher recurrence rate?
A
complete mole
13
Q
partial mole on US
A
- placenta w/ cystic spaces
- fetus
- reduced amniotic fluid volume
- theca lutein cysts absent
14
Q
choriocarcinoma
A
- malignancy of trophoblast
- gestational
- bleeding
- toxemia (pre-eclampsia)
- hypERthyroidism
- METS
- high chemosensitive
- high hCG
15
Q
currant juice bleeding
A
choriocarcinoma
