Breast Disorders, Breast Pathology Flashcards

1
Q

common causes of glactorrhea

A
  • xs stim
  • prolactinoma
  • hypOthyroid
  • DA antagonists
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2
Q

bloody nipple discharge causes

A

intaductal papilloma

breast cancer

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3
Q

intraductal papilloma

A
  • lactiferous duct, usu 2-4mm, solitary
  • bloody/serous discharge (arise in lactiferous duct
  • women 30-50 y/o
  • multiple + atypia –> underlying cancer
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4
Q

Paget’s

A

skin involvement with underlying breast cancer

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5
Q

clinical breast exam recommendation

A

25-39: every 1-3 years

greater than 40: every year

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6
Q

screening mammography guidelines

A

~1-2 years starting at 40-50

annual >50

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7
Q

fibrocystic breast disease tx

A

NSAIDs
supportive bras
pill/patch/ring

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8
Q

fibroadenomas

A
  • most comm breast mass in younger women
  • firm, well-circumscribed, mobile, non-tender
  • may fluctuate slowly

shrink: menopause
grow: preg (via inc estrogen)

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9
Q

firm, fixed, feels stuck to chest wall

A

breast cancer

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10
Q

Phyllodes tumor

A

rare
younger women
single breast, lg, germ

RAPIDLY grown but rarely mets

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11
Q

mastitis tx

A

dicloxacillin QID

CONTINUE BREASTFEEDING/PUMPING

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12
Q

benign breast diseases

A
fibrocystic change
fibroadenoma
fat necrosis (traumatic)
acute mastitis
intraductal papilloma*
phyllodes*
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13
Q

malignant phyllodes is a

A

sarcoma

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14
Q

benign, non-proliferative disease

A

adenosis
apocrine metaplasia
duct ectasia
ductal hypERplasia of usual type

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15
Q

slightly inc risk of breast CA

A

(WITHOUT ATYPIA)

  • ductal hyperplasia of usual type, moderate or florid
  • intraductal papilloma
  • sclerosis adenosis
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16
Q

fibrocystic change

A

25-45 y/o

-cysts, apocrine metaplasia, fibrosis, calcification, chronic inflammation, ductal hyperplasia

17
Q

High risk of invasive breast CA

A

carcinoma in situ (non-invasive malignancy)

18
Q

Ductal carcinoma in situ

A

DCIS

  • intact BM
  • microcalcifications
  • often multicentric, may be extensive
19
Q

DCIS tx

A

surgery and hormonal

20
Q

estrogen and progesterone receptor expression predicts response to

A

hormonal therapies…

tamoxifen
aromatase inhibitors
fulvestrant

21
Q

HER2 oncoprotein/oncogene status predicts response to

A

trastuzumab

22
Q

HER2+ tumors have a _____ prognosis

A

HER2+ tumors have a WORSE prognosis

23
Q

Inflammatory breast carcinoma

A
  • erythematous, swollen breast
  • peau d’orange
  • tumor present in dermal lymphatics
  • POOR PROGNOSIS (stage T4d)
24
Q

most common type of invasive breast CA

A

invasive ductal CA

25
Q

most common benign tumor of the breast

A

fibroadenoma

26
Q

fibroadenoma

A
  • biphasic, stromal epithelial
  • most common benign tumor of breast
  • young women <30
  • well-circumscribed, movable mass
  • UOQ
27
Q

Is malignant phyllodes common?

A

No, rare

28
Q

most common cause of bloody/serous discharge

A

intraductal papilloma

29
Q

which meds can cause galactorrhea

A

DA antagonists