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Estelle Royal College > GeneticsCYP-EO > Flashcards

GeneticsCYP-EO Flashcards

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1
Q

What is the heritability of GAD

A

30%

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2
Q

What is risk ratio of 1st degree relative with GAD to gen pop

A

6 x

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3
Q

What is risk ratio of 1st degree relative with ADHD to gen pop

A

2-8

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4
Q

What is risk ratio of 1st degree relative with schizophrenia to gen pop

A

10

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5
Q

What is risk ratio of 1st degree relative with BAD to gen pop

A

7-10

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6
Q

What is risk ratio of 1st degree relative with MDD to gen pop

A

3

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7
Q

What is risk ratio of 1st degree relative with OCD to gen pop

A

4

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8
Q

What is the heritability of schizophrenia

A

50-89

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9
Q

What is the heritability of BAD?

A

60-85

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10
Q

What is the heritability of MDD?

A

40

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11
Q

What is the heritability of OCD?

A

30-45

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12
Q

What is the heritability of ADHD?

A

75%

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13
Q 
What is the prevalence of SUD in:
1 ASPD
2 BAD
3 Scz
4 MDD
A

1 -84%
2 -56%
3 -47%
4- 27%

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14
Q

What is the RR of substance use if:
One parent has SUD?
2 parents have SUD?
Father has ETOH and criminality?

A

2-4 for one parent
2-10 for 2 parents
9-18 if father

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15
Q

which antidepressant is a 2D6 substrat?

A 
fluvoxamine
Prozac
Paxil
Sertraline
Duloxetine
Venlafaxine
Mirtazapine
Trazodone
Vortioxetine
TCA (secondary and tertiary amines)
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16
Q

Which antipsychotics is a substrate of 2D6?

A 
Haldol
Olanzapine
Risperidone
Aripiprazole
FGA
17
Q

Which psychostimulants are substrate of 2D6?

A

Amphetamines (dexedrine and adderall)

Atomoxetine

18
Q

Which class other than psychotropics are substrat of 2D6

A

Opioids (codeine methadone morphine)
B-blockers
Tamoxifen

19
Q

Which meds are inducers of 2D6?

A

Rifampin
Phenytoin
Carbamaxepine

20
Q

Which antidepressants are 2D6 inhibitors?

A 
Prozac
Paxil
Dulox
buproprion
Sertraline
es/citalopram
TCA (tertiary and secondary amines)
21
Q

Which antipsychotics are 2D6 inhibitors?

A

Abilify
Risperidone
Haldol

22
Q

Which meds other than psychotropics are 2D6 inhibitors?

A 
CBD
Cocaine
Methadone
Amiodarone
Quinidine
Terbinafine
23
Q

Which antidepressant is a 3A4 substrat?

A 
Sertraline
Fetzima
Vilazodone
Buspirone
Trazodone
TCA tertiary amines
24
Q

Which antipsychotics are 3A4 substrats?

A 
Abilify
Lurasidone
Seroquel
Ziprasidone
Haldol
Clozapine (less than 1A2)
25
Q

Which bezos are 3A4 substrats?

A

Alprazolam

Diazepam

26
Q

Which meds other than psychotropics are 3A4 substrats?

A 
Oxy
Cocain
Fentanyl
Statines
Tamoxifen
27
Q

Which meds are 3A4 inducers?

A 
St-John wart
Modafinil
Rifampin
Phenytoin
Phenobarb
Carbamazepine/oxcarbamazepine
Prednisone/glucocorticoids
HIV meds
Topamax
28
Q

What inhibits 3A4?

A 
Fluvoxamine
Jus de pamplemousse
Amiodarone
Antifungals (azoles)
THC/CBD
HIV meds
Macrolides (clarythro)
29
Q

Which antidepressants are 1A2 substrats?

A

Fluvoxamine
Agomelatine
Mirtazapine
TCA (tertiary - clomi, amitr, imi)

30
Q

Which antipsychotics are 1A2 substrats?

A

Clozapine
Haldol
Olanzapine

31
Q

What other substance are 1A2 substrat?

A

Café
Warfarine
Methadone
Acetaminophene

32
Q

Which susbstance induce 1A2?

A 
Cigarette
BBQ
Modafinil
Insuline
Marijuana
Choux de bruxelle
Broccoli
Phenytoine
Rifampin
Rifampin
33
Q

Which substance inhibits 1A2?

A

Fluvox
Cimetidine
Amiodarone
Fluoroquinolones (cipro)

Estelle Royal College (23 decks)

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