GDM and MODY

Question 1

what is GDM?

Answer 1

diabetes that arises in pregnancy, usually in 2nd or 3rd trimester

Question 2

what happens post-natally for women with GDM?

Answer 2

6 week post natal check

lifelong testing every 3 years

Question 3

what is MODY?

Answer 3

maturity onset diabetes of the young

Question 4

MODY AD mutations

Answer 4

1. glucokinase
2. transcription factors
3. neonatal

Question 5

glucokinase MODY presentation

Answer 5

hyperglycaemia from birth
fasting blood glucose is higher e.g. 7mmol/L not 5
stable as body can adapt

Question 6

management of MODY glucokinase

Answer 6

diet

Question 7

presentation of transcription factor MODY

Answer 7

blood glucose is normal at birth with progressive hyperglycaemia at adolescence

Question 8

management of transcription factor MODY

Answer 8

diet
SUs
insulin

Question 9

what does neonatal diabetes require?

Answer 9

requires insulin within first 3 months of life

Question 10

two types of neonatal diabetes?

Answer 10

1. transient= resolves around 12 weeks

2. permanent

Question 11

examples of monogenic diabetes syndromes

Answer 11

neonatal diabetes

MODY

Question 12

examples of diseases of exocrine pancreas that can have diabetes

Answer 12

CF
haemochromatosis
pancreatitis

Question 13

endocrine diseases that can have diabetes

Answer 13

Cushing’s
acromegaly
phaeochromocytoma
glucagonoma

Question 14

drug/chemical-induced diabetes

Answer 14

steroids
diuretics
beta blockers
HIV/AIDs treatment
after organ transplant

Question 15

genetic diseases that can have diabetes

Answer 15

CF
myotonic dystrophy
Turner’s syndrome