Fungal Disease of Lung Flashcards
What is the most organ affected by the fungal infection
-lung
-skins
What is the risk factor of histoplasmosis
-farmer exposed to the bats and birds excreta
What is the risk factor of spirotrichosis
-farmer with wound exposed to soil
What is the main risk factors of fungal infection
Immunosupression
-genetic
-congenital
-acquired
-postspenectomy
-bone marrow transplantation
What is the yeast causative agent
candidiasis
What is the hypae causative agent
aspargellosis
What is the dimorphic fungal causative agent
-histoplasmosis
-blancomycosis
-coccidiomycosis
What is PJP
-unicellular fungus
-the most common opportunistic infection in patient HIV patient
What is the symptoms of PJP
-fever
-nonproductive cough
-progressive exertion dyspnea
What is the stain used in PJP
GMS stain
What is the microscopic findings of the PJP
-amphopheric
-foamy plugs of parasites
-cellular debris
What is the immunofluorescene findings of PJP
-headshape
-cupshape
-crescent
What is the best investigation in PJP
-sputum induction
-the least invasive and quickest
What is the ttt of PJP
-TMP-SMX (first line)
-dapsone
What is the major predisposing factors leading to aspargellosis
-neutropenia
-corticosteroid
What does the spore of aspergillus causes
-ABPA
What are the types of aspargellosis
-invasive
-chronic (aspargelloma)
-allergic (ABPA)
What are the symptoms of invasive aspergillosis
-hemoptysis
-fever
-leukocytosis (viral infection)
What is the radiological findings of aspargellosis
-halo signs
What is the radiological findings of aspargelloma
-radiolucent crescent
What is the type of cell of Histoplasma capsulatum
-intracellular pathogens
-hides inside the macrophage
What is the general finding of histoplasmosis
-upper love cavitation
-caseating necrosis
What is the post-ttt finding of histoplasmosis
-calcification and fibrosis giving treebark appearance
What is the microscopic finding of histoplasmosis
-thin halo (due to its character that hides inside of the macrophage)
What is the dissemination finding of histoplasmosis in case of immunosupressed patients
-focal accumulation of mononucleated phagocytes
What is the clinical presentation of histoplasmosis
-TB like symptoms
What is blastomycosis
-soil inhabited
-dimorphic fungus
What are the clinical forms of blastomycosis
-pulmonary
-dissemination
-primary cutaneous
What are the symptoms of pulmonary blastomycosis
-acute productive cough
-chest pain
-headache
-night sweat
-loss weight
What are the general finding of blastomycosis
-suppurative granuloma
What are the microscopic of blastomycosis
-double contoured cell wall
-visible nuclei
What is the characters of coccidioides based on;
-hypersensitivity
-symptoms
-lesion morphology
-delayed type
-typically asymptomatic
-as histoplasmosis
When will the pyogenic reaction superimposed in coccidiomycosis
-the rupture of spherules releasing endospores
When will the pyogenic reaction superimposed in coccidiomycosis
-the rupture of spherules releasing endospores
