Frontotemporal Dementia Flashcards
1
Q
What is frontotemporal dementia?
A
- Neurodegenerative proteinopathy
- Protein aggregation causing cell damage
- Early onset dementia
2
Q
Who gets frontotemporal dementia?
A
25% genetic cause
Can be part of a MND
Rarer form of dementia, usually early onset before age 65
3
Q
Presentation of frontotemporal dementia?
A
- Behavioural variation
- 2 forms of primary progressive aphasia
- Early frontal features- disinhibition, apathy, loss of empathy, stereotyped or compulsive behaviours, hyperorality, disinhibition
- Early loss of insight
4
Q
Investigation of frontotemporal dementia?
A
MRI: Atrophy of frontotemporal lobes
SPECT: Frontotemporal, decreased metabolism
CSF increased tau/normal amyloid
5
Q
Chill treatment of frontotemporal dementia?
A
Controlled access to food/money/internet
- Structured activities
- Power of attorney
- Support- MND nurse specialist if coexistent MND
6
Q
Pharmacological treatment?
A
Trial of trazadone/antipsychotics
7
Q
Genetics involved?
A
Some people it is related to C9ORF gene
8
Q
How does FTD contrast from AD?
A
Behaviour chnages are initial pesentation, whereas in AD behaviour cnages are later on presentation
