Eaton Lambert Syndrome Flashcards
1
Q
What is Eaton Lambert Syndrome?
A
Paraneoplastic manifestation of small cell bronchial carcinoma
2
Q
What is ELS due to?
A
Defective ACh release at NMJ
3
Q
Presentation of ELS?
A
- Proximal limb weakness sometimes with ocular or bulbar muscles develops with some absent tendon reflexes
- Weakness tends to improve after few mins of muscular contraction and absent reflexes return
4
Q
Diagnosis confirmed for ELS by?
A
Repetitive nerve stimulation
5
Q
What is found in most cases of ELS
A
ABs to voltage-gated calcium channels
6
Q
Treatment of ELS?
A
3,4-diaminopyridine
