Forces acting against membranes Flashcards
The cell membrane separates the
ECF and ICF
Cell membrane is responsible for maintaining
the difference in composition between the ECF and ICF
There is no barrier to
water movement
Ions can pass through the
capillary wall
K+ is high in…… and low in ….
ICF
ECF
Na+ is low in …. but high in ….
ICF
ECF
Cell membrane is a ………. barrier
selective
Permeability can…
vary
head of a phosphoplipid is
hydrophilic and lipophobic
tail of a phospholipid is
hydrophobic and lipophilic
There is also a difference in charge across the cell membrane. this creates….
an electrical gradient
To diffuse through the lipid bilayer molecules need to be
small
lipophilic
UNCHARGED
water can pass through
aquaporins
Voltage-gated channels
open/close in response to alterations in the membrane electrical potential (charge difference either side of the membrane)
Ligand gated channels
open/close when they blind a chemical such as neurotransmitter or hormone to a receptor binding site on the channel protein
Movement of molecules against their electrochemical gradients requires energy (ATP) and is known as
active transport
H2O is inversely related to the
concentration of solute
the more solute particles there are in solution - the more they will ………. H20
displace
therefore lowering the concentration of h20
DIFFUSION
If a solution of different concentration is separated by a membrane permeable to water AND solute - then after time both will end up with equal ……. and equal ……..
concentration and volume
If a solution of different concentration is separated by a membrane permeable ONLY to water - then after a time it will end up with…
equal concentrations either side of the membrane but
DIFFERENT VOLUMES
Osmotic pressure
the pressure required to prevent water movement
Osmolarity
measures the concentration of biological solutions in unit of OSMOLES and describes the number of particles/L in solution
Normal human plasma osmolarity
the same as within cells
285 mOsmol/l (often 300)
The cell volume at any time is dependent on the concentration of….
non-penetrating solutes on either side of the membrane
Non-penetrating solutes
ECF = Na+ Cl-
ICF = K+
Osmolarity
total number of particles in solution
Tonicity
number of non-penetrating particles in solution
tonicity is much more important as it determines
cell volume
An iso-osmotic solution has
the same total number of solute particles as ECF (plasma)
Hypo-osmotic
solutions with fewer total solute particles
Hyper-osmotic
solution with greater number of total solute particles
hypotonic
solutions with FEWER non-penetrating solute particles
hypertonic
solution with greater number of non-penetrating solute particles
cells in a hypotonic solution will
swell
water enters
cells in a hypertonic solution will
shrink
water leaves