Essential Pharmacology

Question 1

steroid hormones are lipid

Answer 1

soluble

Question 2

steroid hormones bind to

Answer 2

intracellular receptors

Question 3

plasma membrane receptors 4 types

Answer 3

act as ion channels

intrinsic enzymes activity

interact with JAK kinases

interact with G-proteins

Question 4

GPCRs are coupled to

Answer 4

adenylyl cyclase

phospholipase C

directly to ion channels

Question 5

GPCR coupled to ion channel produce …………. EPSPs and IPSPs

Answer 5

SLOW

Question 6

Ionotropic plasma membrane receptors produce …….. EPSPs and IPSP

Answer 6

FAST

Question 7

Calcium can act as a

Answer 7

second messenger

Question 8

phospholipase C produces

Answer 8

DAG that regulated PKC and IP3

they regulated Ca2+

Question 9

low EC50 indicated ………….affinity

Answer 9

high

Question 10

how good the drug is at activating the receptor

Answer 10

efficacy

Question 11

Clinical applications in the NMJ

Answer 11

paralysis (non or depolarising blockers)

botulinum toxin

anti-cholinesterases

Question 12

muscarinic agonists

Answer 12

mimic the effects of the parasympathetic NS

Question 13

muscarinic antagonists

Answer 13

block the effects of the parasympathetic NS