Fitz9. Part 6. Ch 36. Sweet Syndrome

Question 1

Case of 30-60 yo Female with tender/ painful purple red papules/ nodules that are transparent with the “illusion of vesiculation”

1. Disease?
2. Histopath?

Answer 1

1. Sweet syndrome

2. dense dermal inflammatory infiltrate of MATURE neutrophils in upper dermis

Question 2

Major criteria of Sweet syndrome (2)

Answer 2

1. abrupt painful erythematous plaques/ nodules

2. H: dense MATURE neutrophilic infiltrate (no LCV)

Question 3

minor criteria of Sweet syndrome (3-6)

*need to fulfill 2 minor

Answer 3

3. pyrexia (fever > 38C)
4. acute myelogenous leukemia.
   Cancer: Visceral malignancy: breast, GIT, GUT); inflam disease: Crohn, UC; pregnant; preceded by URTI, GIT or vaccination (BCG, influenza)
5. excellent response with systemic steroid or KOH
6. abnormal lab (3/4)
   ESR >20, CRP +, leukocytes >8000, neutrophils >70