Fitz9. Ch13: Principles Of Immunity

Question 1

HLA Haplotypes assoc in
SJS/TEN ALLOPURINOL
SJS/TEN CARBAMAZEPINE
DAPSONE hypersensitivity Syndrome

Answer 1

SJS/TEN ALLOPURINOL: B58:01
SJS/TEN CARBAMAZEPINE: B15:02
DAPSONE hypersensitivity Syndrome: B13:01

Question 2

Disease wherein Peripheral eosinophilia is the hallmark feature and there may be deactivation of herpes virus infections

Answer 2

DRESS

Question 3

Disease with increased serum IgE and CCL17; filaggrin mutation

Answer 3

Atopic dermatitis

Question 4

SPINK5 mutation associated not with AD but with elevated IgE levels in patients with atopic dermatitis

Answer 4

Netherton Syndrome

Question 5

STAT3 SNP

Answer 5

Job syndrome

Question 6

Blocks IL-4 and IL-13 and is effective for atopic dermatitis

Answer 6

DUPILUMAB

Question 7

Inhibit both JAK1 and JAK3 for rheumatoid arthritis, psoriasis, alopecia areata

Answer 7

TOFACITINIB

RUXOLITINIB

Question 8

Anti-TNF alpha for inflammatory bowel disease and psoriasis

Answer 8

INFLIXIMAB