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Mar Der > Fitz9. Ch5. Growth And Differentiation Of Epidermis > Flashcards

Fitz9. Ch5. Growth And Differentiation Of Epidermis Flashcards

1
Q

Highly proliferative but short lived cell population

A

Transient amplifying cells

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2
Q

Tissue micro environment in which stem cells normally exist. Dispersed in the basal layer or rete ridges

A

Niche

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3
Q

Markers for granular layer

A

Loricrin and filaggrin

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5
Q

Spinous cells have keratin

Mutated in what disease

A

Keratin 1 and 10

Epidermolysis hyperkeratosis

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7
Q

A commitment factor for transitional basal cells to spinous cells

A

Notch signaling

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8
Q

Regulators of granular layer

A

Klf4

GRHL3

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9
Q

Regulator of epidermal differentiation

  1. Spinous layer that promote differentiated cell fate versus
  2. Basal layer that promote basal cell fate and recruit methyltransferase
A

Spinous : TINCR

Basal: ANCR

‘AB, ST’

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10
Q

Basal progenitor cells are expressed in keratin ___ and ___

Mutated in what disease

A

Keratin 5 and 14

Epidermolysis bullosa

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11
Q

Granules are composed of

A

Keratins, profilaggrin, Loricrin

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Mar Der (21 decks)

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