Fitz9. Ch4: Development Biology of the Skin

Question 1

Central regulator of epithelial identity

Answer 1

P63

Germinativum

Question 2

Hair follicle formation

Answer 2

Shh ligands

Question 3

Hair follicle formation

Answer 3

EDAR or ectodysplasin A receptor

Question 4

Regulate hair follicle cycling and growth

Answer 4

BMP or bone morphogenic protein

Question 5

Large scale body patterning

Answer 5

HOX or homeobox

Question 6

What germ layer forms the epidermis, melanocytes, and nervous system?

Answer 6

ECTOderm

Question 7

Epidermolysis bullosa lacks these keratins

Answer 7

Keratin 1 and 2

Question 8

Ichthyosis vulgaris

Answer 8

Filaggrin

Question 9

Berardinelli siep lack of adipose development occurs from defects in lipids synthesizing

Answer 9

AGPAT2

Question 10

Goltz syndrome or focal dermal hypoplasia are soft yellow to red nodules in lines of blaschko due to what defect

Answer 10

PORC

Question 11

Dermal fibroblast progenitor

Upper papillary due to collagen ___
Lower reticular due to collagen ___

Answer 11

Upper papillary due to collagen 3

Lower reticular due to collagen 1

Question 12

Fibroblast that promote scarring

Answer 12

Engrailed expression

Question 13

Brown adipose, which functions in burning energy

Answer 13

Prdm16

Question 14

Precursor for melanocytes

Answer 14

SOX10

Question 15

Port-wine stain on the face, with intracranial vasculature anomalies, seizures and mental retardation.
Disease?
Mutation?

Answer 15

Sturge-Weber syndrome

GNAQ

Question 16

Mosaicism commonly has

Answer 16

Blaschko lines

Question 17

Estimated gestational age for epidermal development in

Melanocytes
Langerhan cells
Merkel cells

Answer 17

Melanocytes 8
Langerhan cells 10
Merkel cells 12

Question 18

Gestational age for appendageal development

Dental placodes
Nail placodes
Hair follicle placodes
Sweat gland placodes

Answer 18

Dental placodes 8
Nail placodes 9*
Hair follicle placodes 10
Sweat gland placodes 12